Brainstem Low-Grade Gliomas in Children-Excellent Outcomes With Multimodality Therapy.
Brainstem Low-Grade Gliomas in Children-Excellent Outcomes With Multimodality Therapy.
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DOI：
10.1177/0883073816675547
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发表时间：
2017-03
影响因子：
1.9
通讯作者：
Robertson PL
中科院分区：
文献类型：
--
作者：
Upadhyaya SA;Koschmann C;Muraszko K;Venneti S;Garton HJ;Hamstra DA;Maher CO;Betz BL;Brown NA;Wahl D;Weigelin HC;DuRoss KE;Leonard AS;Robertson PL
安全的最大手术切除是儿童脑干低级别胶质瘤的首选治疗方法。不完全切除肿瘤或手术后进展不确定的最佳治疗。我们回顾了1993年至2013年在密歇根大学治疗的所有非顶盖脑干低级别胶质瘤儿童的临床特征，治疗和结局。诊断时的中位年龄为6岁; 25例肿瘤中有23例得到组织学证实，其中64%为毛细胞星形细胞瘤。19例患者接受了初次肿瘤切除术; 14/19例未接受前期辅助治疗。研究中有8名患者出现疾病进展; 5名最初切除的肿瘤在肿瘤复发时接受了化疗，所有患者均出现部分或完全放射学缓解。10年无进展生存率为71%，总生存率为100%。这项单机构回顾性研究证明了脑干低级别胶质瘤儿童的良好生存率。耐受性良好的化疗在本系列中的疗效支持其在治疗不可切除或进行性脑干低级别胶质瘤中的作用。
Safe maximal surgical resection is the initial treatment of choice for pediatric brainstem low-grade gliomas. Optimal therapy for incompletely resected tumors or that progress after surgery is uncertain. We reviewed the clinical characteristics, therapy, and outcomes of all children with nontectal brainstem low-grade gliomas treated at the University of Michigan between 1993 and 2013. Median age at diagnosis was 6 years; histology was confirmed in 23 of 25 tumors, 64% were pilocytic astrocytoma. Nineteen patients underwent initial tumor resection; 14/19 received no upfront adjuvant therapy. Eight patients in the study had progressive disease; 5 initially resected tumors received chemotherapy at tumor relapse, all with partial or complete radiographic responses. Ten-year progression-free survival is 71% and overall survival, 100%. This single-institution retrospective study demonstrates excellent survival rates for children with brainstem low-grade gliomas. The efficacy of the well-tolerated chemotherapy in this series supports its role in the treatment of unresectable or progressive brainstem low-grade gliomas.
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影响因子：
45.3
作者：
Bowers, Daniel C.;Liu, Yan;Oeffinger, Kevin C.
通讯作者：
Oeffinger, Kevin C.
影响因子：
15.9
作者：
Gnekow, Astrid K.;Falkenstein, Fabian;Faldum, Andreas
通讯作者：
Faldum, Andreas
影响因子：
4.8
作者：
Jallo, GI;Shiminski-Maher, T;Epstein, F
通讯作者：
Epstein, F
影响因子：
1.9
作者：
Lundar, Tryggve;Due-Tonnessen, Bernt Johan;Due-Tonnessen, Paulina
通讯作者：
Due-Tonnessen, Paulina
DOI：
10.1097/pai.0000000000000024
发表时间：
2015-09-01
影响因子：
1.6
作者：
Brown, Noah A.;Weigelin, Helmut C.;Betz, Bryan L.
通讯作者：
Betz, Bryan L.