Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants.
Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants.
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DOI：
10.1016/j.placenta.2008.07.001
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发表时间：
2008-10
期刊：
影响因子：
3.8
通讯作者：
Roberts, J. M.
中科院分区：
文献类型：
--
作者：
Shibata, E.;Hubel, C. A.;Powers, R. W.;von Versen-Hoeynck, F.;Gammill, H.;Rajakumar, A.;Roberts, J. M.
子痫前期和宫内生长受限(IUGR)均与母体胎盘部位螺旋动脉异常重构有关。这预计会与胎儿生长减少有关，然而，患有先兆子痫的母亲的婴儿中只有三分之一的婴儿生长受限。患有IUGR的婴儿血液中氨基酸浓度降低，胎盘中A系统氨基酸转运体活性降低。由于先兆子痫的婴儿循环氨基酸增加，我们检测了小于胎龄儿(SGA)伴和不伴母体先兆子痫的胎盘绒毛碎片的A系统氨基酸转运活性，以及无并发症和正常大小的子痫前期妊娠的胎盘绒毛碎片的氨基酸转运活性。我们证实了无先兆子痫的SGA孕妇对氨基酸的摄取减少，但报告有母体先兆子痫的SGA婴儿的胎盘氨基酸摄取没有减少，并且与正常妊娠和正常体重的先兆子痫婴儿的摄取相同。
Preeclampsia and intrauterine growth restriction (IUGR) are both associated with abnormal remodeling of maternal spiral arteries perfusing the placental site. This would be expected to be associated with reduced fetal growth, yet only one third of infants of mothers with preeclampsia are growth restricted. Infants with IUGR have decreased concentrations of amino acids in their blood and system A amino acid transporter activity is reduced in their placentas. Since infants of preeclamptic pregnancies have increased circulating amino acids, we tested system A amino acid transport activity of placental villous fragments from pregnancies with small for gestational age (SGA) infants with and without maternal preeclampsia and from uncomplicated and preeclamptic pregnancies with normal sized infants. We confirm the reduced uptake of amino acids in SGA pregnancies without preeclampsia but report that placental amino acid uptake of SGA infants with maternal preeclampsia is not reduced and is identical to uptake by normal and preeclamptic pregnancies with normal weight infants.
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影响因子：
3.8
作者：
Mayhew, TM;Ohadike, C;Ong, SS
通讯作者：
Ong, SS
DOI：
10.1111/j.1471-0528.2006.00882.x
发表时间：
2006-05-01
影响因子：
5.8
作者：
Egbor, M;Ansari, T;Sibbons, PD
通讯作者：
Sibbons, PD
影响因子：
3.8
作者：
Mayhew, T. M.;Manwani, R.;Baker, P. N.
通讯作者：
Baker, P. N.
影响因子：
2.5
作者：
CETIN, I;MARCONI, AM;PARDI, G
通讯作者：
PARDI, G
DOI：
10.1111/j.1471-0528.1986.tb07830.x
发表时间：
1986-10-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
KHONG, TY;DEWOLF, F;BROSENS, I
通讯作者：
BROSENS, I