Severe injury-induced osteoporosis and skeletal muscle mineralization: Are these related complications?
Severe injury-induced osteoporosis and skeletal muscle mineralization: Are these related complications?
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严重损伤诱导的骨质疏松症和骨骼肌矿化：这些是相关的并发症吗？
DOI：
10.1016/j.bonr.2020.100743
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发表时间：
2021-06
期刊：
影响因子：
2.5
通讯作者：
Schoenecker JG
中科院分区：
文献类型：
--
作者：
Moore-Lotridge SN;Ihejirika R;Gibson BHY;Posey SL;Mignemi NA;Cole HA;Hawley GD;Uppuganti S;Nyman JS;Schoenecker JG
重伤患者在康复期间会受到并发症的困扰，比如生物矿化失调。矛盾的是，重伤患者会出现骨质流失（骨质疏松），导致骨骼完整性下降以及脆性骨折风险增加；然而他们的软组织也会出现矿化，导致异位骨化（HO）等并发症。导致重伤患者生物矿化失调的病理生理学机制尚未明确。据推测，这些病理情况是相关联的，即矿化从骨骼“转移”到了软组织部分。本研究的目的是确定重伤诱导的骨质疏松和软组织钙化在受伤后是否在时间上一致。利用烧伤合并骨骼肌损伤的小鼠模型来模拟重伤，结果发现小鼠出现了明显的渐进性骨质流失，最早在受伤后3天即可检测到，并且在受伤后7天出现了明显的软组织矿化。观察到的重伤诱导的骨质疏松和软组织矿化发展之间的时间一致性表明，这些并发症可能有共同的病理生理学机制，尽管还需要进一步的实验。
重伤患者在受伤后可能会出现骨质流失或软组织矿化增加的情况。
据推测，这些病理情况是相关联的，即矿化在不同部分之间“转移”。
在一个小鼠模型中，我们观察到重伤诱导的骨质疏松和软组织矿化之间存在时间一致性。
这些结果支持这些并发症可能有共同病理生理学机制的观点。
Severely injured patients are beleaguered by complications during convalescence, such as dysregulated biomineralization. Paradoxically, severely injured patients experience the loss of bone (osteoporosis), resulting in diminished skeletal integrity and increased risk of fragility fractures; yet they also accrue mineralization in soft tissues, resulting in complications such as heterotopic ossification (HO). The pathophysiology leading to dysregulated biomineralization in severely injured patients is not well defined. It has been postulated that these pathologies are linked, such that mineralization is “transferred” from the bone to soft tissue compartments. The goal of this study was to determine if severe injury-induced osteoporosis and soft tissue calcification are temporally coincident following injury. Using a murine model of combined burn and skeletal muscle injury to model severe injury, it was determined that mice developed significant progressive bone loss, detectable as early as 3 days post injury, and marked soft tissue mineralization by 7 days after injury. The observed temporal concordance between the development of severe injury-induced osteoporosis and soft tissue mineralization indicates the plausibility that these complications share a common pathophysiology, though further experiments are required. Severely injured patients can experience both the loss of bone or the accrual of mineralization in soft tissues following injury. It has been postulated that these pathologies are linked, such that mineralization is “transferred” between compartments. In a murine model, we observed a temporal concordance between severe injury-induced osteoporosis and soft tissue mineralization. These results support the plausibility that these complications share a common pathophysiology.
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影响因子：
6.2
作者：
Borsheim, Elisabet;Herndon, David N.;Hawkins, Hal K.;Suman, Oscar E.;Cotter, Matthew;Klein, Gordon L.
通讯作者：
Klein, Gordon L.
影响因子：
4
作者：
Kaewboonchoo, O.;Sung, F. C.;Kuo, C. T.
通讯作者：
Kuo, C. T.
DOI：
10.1016/j.trsl.2017.06.004
发表时间：
2017-08
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Dey D;Wheatley BM;Cholok D;Agarwal S;Yu PB;Levi B;Davis TA
通讯作者：
Davis TA
影响因子：
2.7
作者：
Hew, Jonathan J.;Parungao, Roxanne J.;Wang, Yiwei
通讯作者：
Wang, Yiwei
影响因子：
4.6
作者：
Gibson, Breanne H. Y.;Duvernay, Matthew T.;Schoenecker, Jonathan G.
通讯作者：
Schoenecker, Jonathan G.