TACC3 transcriptionally upregulates E2F1 to promote cell growth and confer sensitivity to cisplatin in bladder cancer.
TACC3 transcriptionally upregulates E2F1 to promote cell growth and confer sensitivity to cisplatin in bladder cancer.
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DOI：
10.1038/s41419-017-0112-6
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发表时间：
2018-01-22
影响因子：
9
通讯作者：
Huang WR
中科院分区：
文献类型：
--
作者：
Lin ZR;Wang MY;He SY;Cai ZM;Huang WR
越来越多的证据表明，转化酸性卷曲3(TACC3)在广泛的癌症中被解除调控。在本研究中，我们报道TACC3在膀胱癌中显著升高，尤其是在肌肉浸润性膀胱癌(MIBCs)中。膀胱癌患者TACC3表达上调与肿瘤侵袭性、分级、T分期及进展呈正相关。此外，Kaplan-Meier生存分析显示，与肿瘤TACC3低表达的患者相比，肿瘤高表达TACC3的膀胱癌患者预后较差。功能研究发现，TACC3是膀胱癌细胞恶性发展的先决条件，包括细胞增殖和侵袭。此外，TACC3还通过激活E2F1的转录促进了G1/S的转变，最终促进了细胞增殖。值得注意的是，TACC3或E2F1的过度表达表明对顺铂有很高的敏感性。综上所述，这些发现确定了TACC3的肿瘤支持作用，它也可能作为膀胱癌的预后和治疗指标
Accumulating evidence has shown that transforming acidic coiled-coil 3 (TACC3) is deregulated in a broad spectrum of cancers. In the present study, we reported that TACC3 was markedly elevated in bladder cancer, especially in muscle-invasive bladder cancers (MIBCs). The upregulation of TACC3 was positively associated with tumor invasiveness, grade, T stage, and progression in patients with bladder cancer. Furthermore, a Kaplan–Meier survival analysis showed that patients with bladder cancer whose tumors had high TACC3 expression experienced a dismal prognosis compared with patients whose tumors had low TACC3 expression. Functional studies have found that TACC3 is a prerequisite for the development of malignant characteristics of bladder cancer cells, including cell proliferation and invasion. Moreover, TACC3 promoted G1/S transition, which was mediated via activation of the transcription of E2F1, eventually enhancing cell proliferation. Notably, the overexpression of TACC3 or E2F1 indicates a high sensitivity to cisplatin. Taken together, these findings define a tumor-supportive role for TACC3, which may also serve as a prognostic and therapeutic indicator in bladder cancers
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影响因子：
10.5
作者：
Gergely, F;Draviam, VM;Raff, JW
通讯作者：
Raff, JW
影响因子：
--
作者：
Duncan CG;Killela PJ;Payne CA;Lampson B;Chen WC;Liu J;Solomon D;Waldman T;Towers AJ;Gregory SG;McDonald KL;McLendon RE;Bigner DD;Yan H
通讯作者：
Yan H
影响因子：
4.8
作者：
Garriga-Canut, M;Orkin, SH
通讯作者：
Orkin, SH
TACC3在食管鳞状细胞癌中的高表达与不良预后相关
影响因子：
--
作者：
Huang ZL;Lin ZR;Xiao YR;Cao X;Zhu LC;Zeng MS;Zhong Q;Wen ZS
通讯作者：
Wen ZS
影响因子：
1.4
作者：
di Martino E;Tomlinson DC;Knowles MA
通讯作者：
Knowles MA