The dynamic serotonin system of the maternal brain.
The dynamic serotonin system of the maternal brain.
复制标题
DOI：
10.1007/s00737-018-0887-1
复制
发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Lonstein JS
中科院分区：
文献类型：
--
作者：
Lonstein JS
世界各地许多孕妇和产后妇女患有高度焦虑和/或抑郁症，这可能对孕产妇和婴儿的健康产生不利影响。产后和产后情感障碍的一线药物治疗仍然是选择性5-羟色胺再摄取抑制剂（SSRIs），尽管缺乏大型对照研究证明其在生殖妇女中的疗效以及胎儿/新生儿暴露于药物的可能性。产前或产后使用SSRIs或其他调节大脑5-羟色胺系统的药物也令人不安，因为人们对女性中枢5-羟色胺系统在生殖过程中发生的典型变化知之甚少，更不用说非典型变化了。我们确实从一些对女性和雌性实验室啮齿动物的研究中了解到，中枢5-羟色胺系统的许多方面在整个生殖过程中是自然动态的，也受到怀孕压力（母体精神病理学的主要诱发因素）的影响。因此，不应假定SSRIs靶向的母体中枢5-羟色胺系统与未分娩的女性或男性相同。更多关于母体中枢5-羟色胺系统的规范性和压力脱轨变化的信息对于了解5-羟色胺如何参与妊娠和产后人群情感障碍的病因学以及SSRIs用于潜在治疗的最佳用途至关重要。
Many pregnant and postpartum women worldwide suffer from high anxiety and/or depression, which can have detrimental effects on maternal and infant well-being. The first-line pharmacotherapies for prepartum and postpartum affective disorders continue to be the selective serotonin reuptake inhibitors (SSRIs), despite the lack of large well-controlled studies demonstrating their efficacy in reproducing women and the potential for fetal/neonatal exposure to the drugs. Prepartum or postpartum use of SSRIs or other drugs that modulate the brain’s serotonin system is also troubling because very little is known about the typical, let alone the atypical, changes that occur in the female central serotonin system across reproduction. We do know from a handful of studies of women and female laboratory rodents that numerous aspects of the central serotonin system are naturally dynamic across reproduction and are also affected by pregnancy stress (a major predisposing factor for maternal psychopathology). Thus, it should not be assumed that the maternal central serotonin system being targeted by SSRIs is identical to non-parous females or males. More information about the normative and stress-derailed changes in the maternal central serotonin system is essential for understanding how serotonin is involved in the etiology of, and the best use of SSRIs for potentially treating, affective disorders in the pregnant and postpartum populations.
登录
查看更多内容
影响因子：
2.7
作者：
Darnaudéry, M;Dutriez, I;Maccari, S
通讯作者：
Maccari, S
影响因子：
2.9
作者：
Alwan, Sura;Reefhuis, Jennita;Friedman, Jan M.
通讯作者：
Friedman, Jan M.
DOI：
10.1016/j.chc.2015.11.001
发表时间：
2016-04-01
影响因子：
2.4
作者：
Drury, Stacy S.;Scaramella, Laura;Zeanah, Charles H.
通讯作者：
Zeanah, Charles H.
DOI：
10.1111/1471-0528.13143
发表时间：
2015-06-01
影响因子：
5.8
作者：
Charlton, R. A.;Jordan, S.;de Jong-van den Berg, L. T. W.
通讯作者：
de Jong-van den Berg, L. T. W.
影响因子：
7.4
作者：
Britton, John R.
通讯作者：
Britton, John R.