Detecting corpus callosum abnormalities in autism based on anatomical landmarks.
Detecting corpus callosum abnormalities in autism based on anatomical landmarks.
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DOI：
10.1016/j.pscychresns.2010.05.006
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发表时间：
2010-08-30
影响因子：
11.3
通讯作者：
Miles J
中科院分区：
文献类型：
--
作者：
He Q;Duan Y;Karsch K;Miles J
自闭症是一种严重的发育障碍，其神经学基础很大程度上未知。自闭症是自闭症的一个亚型，在群体内表现出更同质的特征。本研究的目的是确定自闭症患者和对照组之间胼胝体的形状差异。从 25 名患者和 18 名对照者的中矢状 MRI 中收集解剖标志。采用欧几里得距离矩阵分析和薄板样条来分析地标形式。在全局和局部进行逐点形状比较。提出了一种新的局部形状比较方案，该方案在其局部坐标系中比较形状的每个部分。基于固有的地标对应关系，在各个形状之间建立了点对应关系。患者和对照组之间的标志形式没有发现显着差异，但患者的膝部内侧和最后部之间的距离明显更短。薄板样条分析显示，在总体平均配置的变形方面，标志性配置之间存在显着的组间差异。下体前部和后底部存在显着的整体形状差异，前底部存在局部形状差异。该研究可为今后类似研究提供临床参考和详细的程序指南。
Autism is a severe developmental disorder whose neurological basis is largely unknown. Autism is a subtype of autism that displays more homogeneous features within group. The aim of this study was to identify the shape differences of the corpus callosum between patients with autism and the controls. Anatomical landmarks were collected from mid-sagittal MRI of 25 patients and 18 controls. Euclidean distance matrix analysis and thin-plate spline were used to analyze the landmark forms. Point-by-point shape comparison was performed both globally and locally. A new local shape comparison scheme was proposed which compared each part of the shape in its local coordinate system. Point correspondence was established among individual shapes based on the inherent landmark correspondence. No significant difference was found in the landmark form between patients and controls, but the distance between interior genu and posterior most was found significantly shorter in patients. Thin-plate spline analysis showed significant group difference between the landmark configurations in terms of the deformation from the overall mean configuration. Significant global shape differences were found in the anterior lower body and posterior bottom, and local shape difference existed in the anterior bottom. This study can serve as both clinical reference and a detailed procedure guideline for similar studies in the future.
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影响因子：
3.7
作者：
Moses, P;Courchesne, E;Edwards, E
通讯作者：
Edwards, E
影响因子：
9.9
作者：
Hardan, AY;Minshew, NJ;Keshavan, MS
通讯作者：
Keshavan, MS
影响因子：
10.6
作者：
Liu, Jin-Min;Gao, Wenpeng;Nowinski, Wieslaw L.
通讯作者：
Nowinski, Wieslaw L.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.7
作者：
CLARKE, JM;ZAIDEL, E
通讯作者：
ZAIDEL, E