Noninvasive Imaging of the Coronary Vasculature Using Ultrafast Ultrasound.
Noninvasive Imaging of the Coronary Vasculature Using Ultrafast Ultrasound.
复制标题
使用Ultrafast Ultrasound对冠状动脉血管的无创成像。
DOI：
10.1016/j.jcmg.2017.05.021
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Pernot M
中科院分区：
文献类型：
--
作者：
Maresca D;Correia M;Villemain O;Bizé A;Sambin L;Tanter M;Ghaleh B;Pernot M
本研究的目的是探讨冠状动脉超快多普勒血管造影（CUDA）的潜力，一种新的血管成像技术的基础上超快超声，无创成像与高灵敏度的心肌内冠状动脉血管和量化的冠状动脉血流动力学。无创冠状动脉成像技术目前仅限于观察心外膜冠状动脉。然而，许多研究强调了冠状动脉微循环和微血管疾病的重要性。在9只猪的开胸手术中进行了体内CUDA。将2,000帧/秒的超快平面波成像与自适应时空滤波相结合，以实现冠状动脉血流的超高灵敏度成像。在左前降支（LAD）动脉闭塞30秒后再灌注充血期间进行流量变化的定量，并与放置在LAD近端位置的流量计探头提供的金标准测量值进行比较（n = 5）。在腺苷静脉灌注期间评估冠状动脉血流储备。在第二组实验中评价血管损伤，其中LAD闭塞90分钟，随后再灌注150分钟以诱导心肌梗死（n = 3）。最后，在2名成人和2名儿童志愿者中评估了CUDA的经胸可行性。在1个心动周期内获得静脉和动脉心肌内血流的超高灵敏度电影环。充血期间冠状动脉血流变化的定量与金标准测量结果（r2 = 0.89）以及冠状动脉血流储备评估结果（2.35 ± 0.65 vs. 2.28 ± 0.84; p = NS）一致。在梗塞动物中，CUDA图像显示在再灌注的LAD区域中存在强烈充血和异常冠状动脉血管结构的外观。最后，经胸冠状动脉血管成像的可行性显示在4个人类志愿者。超快多普勒成像可以高灵敏度地标测冠状动脉血管并量化壁内冠状动脉血流变化。
The aim of this study was to investigate the potential of coronary ultrafast Doppler angiography (CUDA), a novel vascular imaging technique based on ultrafast ultrasound, to image noninvasively with high sensitivity the intramyocardial coronary vasculature and quantify the coronary blood flow dynamics. Noninvasive coronary imaging techniques are currently limited to the observation of the epicardial coronary arteries. However, many studies have highlighted the importance of the coronary microcirculation and microvascular disease. CUDA was performed in vivo in open-chest procedures in 9 swine. Ultrafast plane-wave imaging at 2,000 frames/s was combined to an adaptive spatiotemporal filtering to achieve ultrahigh-sensitive imaging of the coronary blood flows. Quantification of the flow change was performed during hyperemia after a 30-s left anterior descending (LAD) artery occlusion followed by reperfusion and was compared to gold standard measurements provided by a flowmeter probe placed at a proximal location on the LAD (n = 5). Coronary flow reserve was assessed during intravenous perfusion of adenosine. Vascular damages were evaluated during a second set of experiments in which the LAD was occluded for 90 min, followed by 150 min of reperfusion to induce myocardial infarction (n = 3). Finally, the transthoracic feasibility of CUDA was assessed on 2 adult and 2 pediatric volunteers. Ultrahigh-sensitive cine loops of venous and arterial intramyocardial blood flows were obtained within 1 cardiac cycle. Quantification of the coronary flow changes during hyperemia was in good agreement with gold standard measurements (r2 = 0.89), as well as the assessment of coronary flow reserve (2.35 ± 0.65 vs. 2.28 ± 0.84; p = NS). On the infarcted animals, CUDA images revealed the presence of strong hyperemia and the appearance of abnormal coronary vessel structures in the reperfused LAD territory. Finally, the feasibility of transthoracic coronary vasculature imaging was shown on 4 human volunteers. Ultrafast Doppler imaging can map the coronary vasculature with high sensitivity and quantify intramural coronary blood flow changes.
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影响因子：
7.5
作者：
Takx, Richard A. P.;Blomberg, Bjorn A.;Leiner, Tim
通讯作者：
Leiner, Tim
影响因子：
3.5
作者：
Provost J;Papadacci C;Arango JE;Imbault M;Fink M;Gennisson JL;Tanter M;Pernot M
通讯作者：
Pernot M
影响因子：
24
作者：
Norgaard, Bjarne L.;Leipsic, Jonathon;Achenbach, Stephan
通讯作者：
Achenbach, Stephan
影响因子：
10.6
作者：
Osmanski, Bruno-Felix;Pernot, Mathieu;Tanter, Mickael
通讯作者：
Tanter, Mickael
DOI：
10.1109/tuffc.2009.1067
发表时间：
2009-03-01
影响因子：
3.6
作者：
Montaldo, Gabriel;Tanter, Mickael;Fink, Mathias
通讯作者：
Fink, Mathias