Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases.
Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases.
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DOI：
10.1038/ajg.2017.97
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Kaplan GG
中科院分区：
文献类型：
--
作者：
Benchimol EI;Bernstein CN;Bitton A;Carroll MW;Singh H;Otley AR;Vutcovici M;El-Matary W;Nguyen GC;Griffiths AM;Mack DR;Jacobson K;Mojaverian N;Tanyingoh D;Cui Y;Nugent ZJ;Coulombe J;Targownik LE;Jones JL;Leddin D;Murthy SK;Kaplan GG
儿童发病的炎症性肠病（IBD）的发病率在全球范围内不断增加。我们使用基于人群的卫生管理数据来确定加拿大国家IBD的发病率、患病率和儿童期发病IBD的趋势。我们从五个省（阿尔伯塔、马尼托巴、新斯科舍省、安大略、魁北克）的卫生行政数据中确定了1999-2010年诊断为IBD的<16岁儿童，占加拿大人口的79.2%。计算每10万儿童的标准化发病率和患病率。采用Poisson回归分析确定发病率和患病率的年度百分比变化（APC）。使用随机效应模型对省级估计值进行荟萃分析，以产生全国估计值。在研究期间诊断出5，214例事件病例（3，462例克罗恩病，1，382例溃疡性结肠炎，279例无法分类）。加拿大的发病率为9.68（95% CI 9.11 - 10.25）/100，000儿童。大多数省份的发病率相似，但新斯科舍省的发病率较高。在整个队列中，APC的发生率在研究期间没有显著变化（+2.06%，95%CI-0.64%至+4.76%）。而0- 5岁儿童的发病率显著增加（+7.19%，95%+2.82%至+11.56%）。在加拿大研究期结束时的患病率为每100，000名儿童38.25（95% CI 35.78至40.73）。患病率随时间显著增加，APC为+4.56%（95%CI为+3.71%至+5.42%）。加拿大是世界上儿童期发病IBD发病率最高的国家之一。随着时间的推移，患病率显著增加。除了最年幼儿童组的发病率迅速增加外，发病率没有统计学变化。
The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide. We used population-based health administrative data to determine national Canadian IBD incidence, prevalence, and trends over time of childhood-onset IBD. We identified children <16 years (y) diagnosed with IBD 1999–2010 from health administrative data in five provinces (Alberta, Manitoba, Nova Scotia, Ontario, Quebec), comprising 79.2% of the Canadian population. Standardized incidence and prevalence were calculated per 100,000 children. Annual percentage change (APC) in incidence and prevalence were determined using Poisson regression analysis. Provincial estimates were meta-analyzed using random-effects models to produce national estimates. 5,214 incident cases were diagnosed during the study period (3,462 Crohn’s disease, 1,382 ulcerative colitis, 279 type unclassifiable). The incidence in Canada was 9.68 (95% CI 9.11 to 10.25) per 100,000 children. Incidence was similar amongst most provinces, but higher in Nova Scotia. APC in incidence did not significantly change over the study period in the overall cohort (+2.06%, 95% CI −0.64% to +4.76%). However, incidence significantly increased in children aged 0–5y (+7.19%, 95% +2.82% to +11.56%). Prevalence at the end of the study period in Canada was 38.25 (95% CI 35.78 to 40.73) per 100,000 children. Prevalence increased significantly over time, APC +4.56% (95% CI +3.71% to +5.42%). Canada has amongst the highest incidence of childhood-onset IBD in the world. Prevalence significantly increased over time. Incidence was not statistically changed with the exception of a rapid increase in incidence in the youngest group of children.
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影响因子：
4.9
作者：
Bitton, Alain;Vutcovici, Maria;Brassard, Paul
通讯作者：
Brassard, Paul
影响因子：
29.4
作者：
Kappelman, Michael D.;Rifas-Shiman, Sheryl L.;Porter, Carol Q.;Ollendorf, Daniel A.;Sandler, Robert S.;Galanko, Joseph A.;Finkelstein, Jonathan A.
通讯作者：
Finkelstein, Jonathan A.
法国加拿大人炎症性肠病的表型和基因型特征：与大型北美存储库进行比较。
影响因子：
9.8
作者：
Bhat, Mamatha;Nguyen, Geoffrey C.;Pare, Pierre;Lahaie, Raymond;Deslandres, Colette;Bernard, Edmond-Jean;Aumais, Guy;Jobin, Gilles;Wild, Gary;Cohen, Albert;Langelier, Diane;Brant, Steven;Dassopoulos, Themistocles;McGovern, Dermot;Torres, Esther;Duerr, Richard;Regueiro, Miguel;Silverberg, Mark S.;Steinhart, Hillary;Griffiths, Anne M.;Elkadri, Abdul;Cho, Judy;Proctor, Deborah;Goyette, Philippe;Rioux, John;Bitton, Alain
通讯作者：
Bitton, Alain
影响因子：
29.4
作者：
Benchimol, Eric I.;Mack, David R.;Muise, Aleixo M.
通讯作者：
Muise, Aleixo M.
影响因子：
5
作者：
Bernstein, CN;Blanchard, JF;Wajda, A
通讯作者：
Wajda, A