In situ fabrication of 3D Ag@ZnO nanostructures for microfluidic surface-enhanced Raman scattering systems.
In situ fabrication of 3D Ag@ZnO nanostructures for microfluidic surface-enhanced Raman scattering systems.
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DOI：
10.1021/nn503826r
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发表时间：
2014-12-23
期刊：
影响因子：
17.1
通讯作者：
Huang, Tony Jun
中科院分区：
文献类型：
--
作者：
Xie, Yuliang;Yang, Shikuan;Mao, Zhangming;Li, Peng;Zhao, Chenglong;Cohick, Zane;Huang, Po-Hsun;Huang, Tony Jun
在这项工作中，我们开发了一种原位方法来生长高度可控的，敏感的，三维（3D）的表面增强拉曼散射（Sers）衬底通过光热效应内的微流控设备。实施这种方法，我们制造的Sers衬底组成的Ag@ZnO结构在规定的位置内的微流体通道，网站内，目前的Sers结构的制造一直是艰巨的。方便地，3D Ag@ZnO纳米结构的性质，如长度，堆积密度和覆盖率也可以通过调节激光照射参数来调节。在探索了3D纳米结构的制备之后，我们展示了高达102 × 106的Sers增强因子，并通过时域有限差分模拟研究了3D Ag@ZnO结构的光学性质。为了说明我们的技术的潜在价值，低浓度的生物分子在液态检测。此外，3D Ag@ZnO结构的集成细胞捕获功能记录了活细胞的表面化学指纹。总的来说，我们的基于光热效应的制造技术提供了微流体与Sers的有效结合，解决了与微流体通道中Sers基底的制造相关的问题。由于其在功能性、简单性和灵敏度方面的优势，所提出的微流体SERS平台在许多生物、生物化学和生物医学应用中应该是有价值的。
In this work, we develop an in situ method to grow highly controllable, sensitive, three-dimensional (3D) surface-enhanced Raman scattering (SERS) substrates via an optothermal effect within microfluidic devices. Implementing this approach, we fabricate SERS substrates composed of Ag@ZnO structures at prescribed locations inside microfluidic channels, sites within which current fabrication of SERS structures has been arduous. Conveniently, properties of the 3D Ag@ZnO nanostructures such as length, packing density, and coverage can also be adjusted by tuning laser irradiation parameters. After exploring the fabrication of the 3D nanostructures, we demonstrate a SERS enhancement factor of up to ∼2 × 106 and investigate the optical properties of the 3D Ag@ZnO structures through finite-difference time-domain simulations. To illustrate the potential value of our technique, low concentrations of biomolecules in the liquid state are detected. Moreover, an integrated cell-trapping function of the 3D Ag@ZnO structures records the surface chemical fingerprint of a living cell. Overall, our optothermal-effect-based fabrication technique offers an effective combination of microfluidics with SERS, resolving problems associated with the fabrication of SERS substrates in microfluidic channels. With its advantages in functionality, simplicity, and sensitivity, the microfluidic-SERS platform presented should be valuable in many biological, biochemical, and biomedical applications.
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