Circadian clocks for all meal-times: anticipation of 2 daily meals in rats.
Circadian clocks for all meal-times: anticipation of 2 daily meals in rats.
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DOI：
10.1371/journal.pone.0031772
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Parfyonov M
中科院分区：
文献类型：
--
作者：
Mistlberger RE;Kent BA;Chan S;Patton DF;Weinberg A;Parfyonov M
大鼠每日进餐的预期被概念化为由食物夹带的昼夜节律振荡器驱动的休息活动节律，该节律与产生明暗（LD）夹带节律的起搏器分开。大鼠还可以预测每天两次进餐时间，但这是否涉及独立引入的振荡器、一个“持续查阅”的时钟、依赖线索的非昼夜节律间隔时间或过程的组合，尚不清楚。大鼠每天接受两餐，从开灯后 3 小时（餐 1）和 13 小时（餐 2）开始（LD 14∶10）。预期轮跑在第一餐前 68±8 分钟开始，在第二餐前 101±9 分钟开始，但预期回合长度的持续时间和变化都没有表现出标量特性，这是间隔计时的标志。 LD 和持续黑暗 (DD) 中的进餐遗漏测试不会改变任一轮预期的时间安排，并且第 1 餐提前 3 小时不会改变第 2 餐的预期。因此，尽管 LD 中存在外部时间线索，但在此 2 餐方案中进行的食物预期运行并未表现出间隔计时的特性。在所有日子里，两轮预期都是不相关的，结果与两个独立夹带的振荡器比单个参考时钟更一致。对于开灯后 3 小时和 10 小时安排的膳食以及食物箱预期测量也获得了类似的结果。在 DD 的 1 或 2 天食物剥夺测试中，大多数对一顿或两顿饭表现出较弱或没有预期的大鼠在进餐时表现出较高的活动，这表明在缺乏预期行为的情况下昼夜节律的秘密运作。一项对照实验证实，白天进食不会改变 LD 引起的节律，从而排除了夜间活动取代作为白天活动的解释。结果支持两餐预期节律的多振荡器基础，并且没有提供涉及线索依赖性间隔计时的证据。
Anticipation of a daily meal in rats has been conceptualized as a rest-activity rhythm driven by a food-entrained circadian oscillator separate from the pacemaker generating light-dark (LD) entrained rhythms. Rats can also anticipate two daily mealtimes, but whether this involves independently entrained oscillators, one ‘continuously consulted’ clock, cue-dependent non-circadian interval timing or a combination of processes, is unclear. Rats received two daily meals, beginning 3-h (meal 1) and 13-h (meal 2) after lights-on (LD 14∶10). Anticipatory wheel running began 68±8 min prior to meal 1 and 101±9 min prior to meal 2 but neither the duration nor the variability of anticipation bout lengths exhibited the scalar property, a hallmark of interval timing. Meal omission tests in LD and constant dark (DD) did not alter the timing of either bout of anticipation, and anticipation of meal 2 was not altered by a 3-h advance of meal 1. Food anticipatory running in this 2-meal protocol thus does not exhibit properties of interval timing despite the availability of external time cues in LD. Across all days, the two bouts of anticipation were uncorrelated, a result more consistent with two independently entrained oscillators than a single consulted clock. Similar results were obtained for meals scheduled 3-h and 10-h after lights-on, and for a food-bin measure of anticipation. Most rats that showed weak or no anticipation to one or both meals exhibited elevated activity at mealtime during 1 or 2 day food deprivation tests in DD, suggesting covert operation of circadian timing in the absence of anticipatory behavior. A control experiment confirmed that daytime feeding did not shift LD-entrained rhythms, ruling out displaced nocturnal activity as an explanation for daytime activity. The results favor a multiple oscillator basis for 2-meal anticipatory rhythms and provide no evidence for involvement of cue-dependent interval timing.
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DOI：
10.1037/h0034666
发表时间：
1973-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BOLLES, RC;MOOT, SA
通讯作者：
MOOT, SA
DOI：
10.1037/0097-7403.20.2.135
发表时间：
1994-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
CHURCH, RM;MECK, WH;GIBBON, J
通讯作者：
GIBBON, J
影响因子：
25
作者：
Jagota, A;de la Iglesia, HO;Schwartz, WJ
通讯作者：
Schwartz, WJ
影响因子：
2.5
作者：
BIEBACH, H;GORDIJN, M;KREBS, JR
通讯作者：
KREBS, JR
影响因子：
3.3
作者：
Angeles-Castellanos, M.;Salgado-Delgado, R.;Escobar, C.
通讯作者：
Escobar, C.