Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans.
Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans.
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DOI：
10.1371/journal.pntd.0005625
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发表时间：
2017-07
影响因子：
3.8
通讯作者：
Weetman D
中科院分区：
文献类型：
--
作者：
Moyes CL;Vontas J;Martins AJ;Ng LC;Koou SY;Dusfour I;Raghavendra K;Pinto J;Corbel V;David JP;Weetman D
埃及伊蚊和伊蚊。白纹伊蚊是5种重要虫媒病毒（即基孔肯雅病毒、登革热病毒、裂谷热病毒、黄热病病毒和寨卡病毒）的主要载体，使这些蚊子成为全球传染病负担的重要因素。使用杀虫剂控制病媒并减少幼虫源对于控制这些病毒向人类传播至关重要，但受到杀虫剂抗药性出现的威胁。在此，我们回顾了全球这 2 个主要病媒对杀虫剂抗药性地理分布的现有证据，并绘制了 4 类主要神经毒性杀虫剂（氨基甲酸酯、有机氯、有机磷酸酯和拟除虫菊酯）整理数据的地图。在美洲、非洲和亚洲均发现了对所有 4 类杀虫剂的新抗药性。目标位点突变和杀虫剂解毒作用的增强都与伊蚊的抗性有关。埃及伊蚊和伊蚊。白纹伊蚊，但需要做更多的工作来进一步阐明代谢机制并开发可靠的诊断方法。为迄今为止已被证明很重要的机制提供了地理分布。由于所使用的诊断工具缺乏标准化以及许多地区缺乏抗药性表型和基因型数据，对未采样地点的杀虫剂抗药性进行估计受到阻碍。使用标准方法增加采样对于解决威胁人类健康的新出现的杀虫剂耐药性问题至关重要。具体来说，用于控制伊蚊的全系列杀虫剂需要诊断剂量和充分表征的敏感菌株。埃及伊蚊和伊蚊。白纹伊蚊以标准化耐药表型的测量，并且需要针对主要耐药机制进行校准的诊断测定。
Both Aedes aegytpi and Ae. albopictus are major vectors of 5 important arboviruses (namely chikungunya virus, dengue virus, Rift Valley fever virus, yellow fever virus, and Zika virus), making these mosquitoes an important factor in the worldwide burden of infectious disease. Vector control using insecticides coupled with larval source reduction is critical to control the transmission of these viruses to humans but is threatened by the emergence of insecticide resistance. Here, we review the available evidence for the geographical distribution of insecticide resistance in these 2 major vectors worldwide and map the data collated for the 4 main classes of neurotoxic insecticide (carbamates, organochlorines, organophosphates, and pyrethroids). Emerging resistance to all 4 of these insecticide classes has been detected in the Americas, Africa, and Asia. Target-site mutations and increased insecticide detoxification have both been linked to resistance in Ae. aegypti and Ae. albopictus but more work is required to further elucidate metabolic mechanisms and develop robust diagnostic assays. Geographical distributions are provided for the mechanisms that have been shown to be important to date. Estimating insecticide resistance in unsampled locations is hampered by a lack of standardisation in the diagnostic tools used and by a lack of data in a number of regions for both resistance phenotypes and genotypes. The need for increased sampling using standard methods is critical to tackle the issue of emerging insecticide resistance threatening human health. Specifically, diagnostic doses and well-characterised susceptible strains are needed for the full range of insecticides used to control Ae. aegypti and Ae. albopictus to standardise measurement of the resistant phenotype, and calibrated diagnostic assays are needed for the major mechanisms of resistance.
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影响因子：
3
作者：
Coleman M;Hemingway J;Gleave KA;Wiebe A;Gething PW;Moyes CL
通讯作者：
Moyes CL
影响因子：
--
作者：
Bellinato DF;Viana-Medeiros PF;Araújo SC;Martins AJ;Lima JB;Valle D
通讯作者：
Valle D
影响因子：
7
作者：
Faucon F;Dusfour I;Gaude T;Navratil V;Boyer F;Chandre F;Sirisopa P;Thanispong K;Juntarajumnong W;Poupardin R;Chareonviriyaphap T;Girod R;Corbel V;Reynaud S;David JP
通讯作者：
David JP
影响因子：
168.9
作者：
通讯作者：
--
DOI：
10.1073/pnas.1608295113
发表时间：
2016-08-16
影响因子：
11.1
作者：
Balabanidou, Vasileia;Kampouraki, Anastasia;Vontas, John
通讯作者：
Vontas, John