Phylloquinone intake, insulin sensitivity, and glycemic status in men and women.
Phylloquinone intake, insulin sensitivity, and glycemic status in men and women.
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DOI：
10.1093/ajcn/88.1.210
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发表时间：
2008-07
期刊：
影响因子：
--
通讯作者：
Jacques PF
中科院分区：
文献类型：
--
作者：
Yoshida M;Booth SL;Meigs JB;Saltzman E;Jacques PF
有限的证据表明，维生素K可能在葡萄糖稳态中发挥有益作用。目前还没有关于维生素K摄入量与胰岛素敏感性之间关系的观察数据。目的是研究年龄在26-81岁的男性和女性中维生素K摄入量与胰岛素敏感性和血糖水平之间的关系。我们评估了自我报告的叶绿醌（维生素K1）摄入量与胰岛素敏感性之间的横截面关联，以及与Frachial Offspring队列中的血糖状态之间的关联。膳食和补充叶绿醌摄入量进行了评估的食物频率问卷。采用空腹及口服葡萄糖耐量试验（OGTT）后2 h胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）和胰岛素敏感性指数（ISI 0，120）测定胰岛素敏感性。通过空腹和OGTT后2小时的血糖和血红蛋白A1 c（HbA 1c）评估糖化血红蛋白状态。较高的叶绿醌摄入量与较高的胰岛素敏感性和血糖状态相关，通过OGTT后2小时胰岛素和葡萄糖测量，在调整年龄，性别，腰围，生活方式特征和饮食质量后，ISI 0，120（OGTT后2小时胰岛素：最低与最高五分位数，81.0与72.7 μU/mL，趋势P = 0.003; ISI 0，120：26.3与27.3 mg·L2/mmol·mU·min，趋势P = 0.01; OGTT后2小时血糖：106.3 vs. 101.9 mg/dL，趋势P = 0.01）。叶绿醌摄入量与空腹胰岛素和血糖浓度、HOMA-IR和HbA 1c无关。我们的研究结果支持叶绿醌在成年男性和女性的葡萄糖稳态中的潜在有益作用。
Limited evidence suggests that vitamin K may have a beneficial role in glucose homeostasis. No observational data exist on the associations between vitamin K intake and insulin sensitivity. The aim was to examine associations between vitamin K intake and measures of insulin sensitivity and glycemic status in men and women, aged 26-81 y. We assessed the cross-sectional associations between self-reported phylloquinone (vitamin K1) intake and insulin sensitivity, and with glycemic status in the Framingham Offspring Cohort. Dietary and supplemental phylloquinone intakes were assessed by food-frequency questionnaire. Insulin sensitivity was measured by fasting and 2-h post oral glucose tolerance test (OGTT) insulin, the homeostasis model assessment of insulin resistance (HOMA-IR) and the insulin sensitivity index (ISI0,120). Glycemic status was assessed by fasting and 2-h post OGTT glucose and hemoglobin A1c (HbA1c). Higher phylloquinone intake was associated with greater insulin sensitivity and glycemic status, as measured by 2-h post OGTT insulin and glucose, and ISI0,120, after adjustment for age, sex, waist circumference, lifestyle characteristics and diet quality (2-h post OGTT insulin: lowest vs. highest quintile, 81.0 vs. 72.7 μU/mL, P for trend = 0.003; ISI0,120: 26.3 vs. 27.3 mg·L2/mmol·mU·min, P for trend = 0.01; 2-h post OGTT glucose: 106.3 vs. 101.9 mg/dL, P for trend = 0.01). Phylloquinone intake was not associated with fasting insulin and glucose concentrations, HOMA-IR and HbA1c. Our findings support a potential beneficial role for phylloquinone in glucose homeostasis in adult men and women.
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影响因子：
4.2
作者：
Booth, SL;Suttie, JW
通讯作者：
Suttie, JW
影响因子：
64.5
作者：
Lee, Na Kyung;Sowa, Hideaki;Karsenty, Gerard
通讯作者：
Karsenty, Gerard
影响因子：
3.8
作者：
REDDI, K;HENDERSON, B;HODGES, SJ
通讯作者：
HODGES, SJ
影响因子：
1.6
作者：
Ohsaki, Y;Shirakawa, H;Komai, M
通讯作者：
Komai, M
影响因子：
--
作者：
FESKANICH, D;RIMM, EB;WILLETT, WC
通讯作者：
WILLETT, WC