Effect of Serotonin (5-HT) on Trigeminal Rhythmic Activities Generated in in vitro Brainstem Block Preparations
Effect of Serotonin (5-HT) on Trigeminal Rhythmic Activities Generated in in vitro Brainstem Block Preparations
复制标题
5-羟色胺（5-HT）对体外脑干阻滞制剂产生的三叉神经节律活性的影响
DOI：
10.1177/154405910208100904
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发表时间：
2002
影响因子：
7.6
通讯作者：
T. Matsuya
中科院分区：
文献类型：
--
作者：
Atsuyuki Mori;M. Kogo;K. Ishihama;Susumu Tanaka;A. Enomoto;H. Koizumi;T. Matsuya
我们使用大鼠离体脑干阻滞制剂来分析血清素受体在三叉神经节律活动产生中的功能作用。我们之前报道过，三叉神经的节律活动可以通过在分离的脑干制剂中的一些药理应用来诱导，该脑干制剂的上丘边界位于下丘和上丘之间的边界，尾部边界位于面核水平。然而，在 obex 水平具有相同头侧边界和尾侧边界的整个脑干块制剂中，相同的刺激不会诱导三叉神经节律活动。在本研究中，5-HT1A 邻苯二甲酰亚氨基丁基哌嗪和 5-HT2C 激动剂 1-2,5-二甲氧基-4-碘苯基-2-氨基丙烷，与 N-甲基-D,L-天冬氨酸和荷包牡丹碱相结合，在整个脑干阻滞制剂中引发了三叉神经节律活动。我们的结果表明，在体外分离的脑干阻滞制剂中，5-羟色胺对三叉神经节律活动的产生具有促进和抑制作用。
We used rat isolated brainstem block preparations to analyze the functional roles of serotonin receptors in the generation of trigeminal rhythmic activities. We previously reported that trigeminal rhythmic activities could be induced by some pharmacological applications in an isolated brainstem preparation with a rostral boundary at the border between the inferior and superior colliculus, and a caudal border at the level of the rostral facial nucleus. However, the same stimulation did not induce trigeminal rhythmic activities in a whole brainstem block preparation with the same rostral boundary and a caudal border at the obex level. In the present study, both the 5-HT1A phthalimido-butyl-piperazine, and the 5-HT2C agonist, 1-2,5-dimethoxy-4-iodophenyl-2-aminopropane, combined with N-methyl-D,L-aspartate and bicuculline, elicited trigeminal rhythmic activities in a whole brainstem block preparation. Our results suggest that serotonin has both facilitation and inhibition effects on the generation of trigeminal rhythmic activities in an isolated brainstem block preparation in vitro.
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影响因子：
56.9
作者：
SMITH, JC;ELLENBERGER, HH;FELDMAN, JL
通讯作者：
FELDMAN, JL
影响因子：
5.5
作者：
GRUDT, TJ;WILLIAMS, JT;TRAVAGLI, RA
通讯作者：
TRAVAGLI, RA
对豚鼠咀嚼样活动期间三叉神经运动神经元放电的药理机制进行离子电渗分析。
影响因子：
2.5
作者：
Katakura,N;Chandler,SH
通讯作者：
Chandler,SH
DOI：
--
发表时间：
1985-05
期刊：
The Journal of experimental biology
影响因子：
--
作者：
R. Harris-Warrick;A. Cohen
通讯作者：
R. Harris-Warrick;A. Cohen