Description of Hymenolepis microstoma (Nottingham strain): a classical tapeworm model for research in the genomic era.

Description of Hymenolepis microstoma (Nottingham strain): a classical tapeworm model for research in the genomic era.
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DOI:
10.1186/1756-3305-3-123
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发表时间:
2010-12-31
影响因子:
3.2
通讯作者:
Olson PD
Olson PD
中科院分区:
医学2区
文献类型:
--
作者:
Cunningham LJ;Olson PD

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小口膜壳绦虫(英语:Hymenolepis microstoma)(Dujardin,1845)Blanchard,1891,小鼠胆管绦虫,是一种啮齿动物/甲虫宿主的实验室模型,自20世纪50年代驯化以来一直用于研究和教学。最近对其基因组的表征促使我们描述支持这些数据的特定菌株,锚定其身份并使150多年的原始描述更新。对用于基因组鉴定的小口膜壳绦虫“诺丁汉”菌株的实验室饲养标本进行了形态测定和超微结构分析。提供了该物种的当代描述,包括成年解剖学的详细说明和其分类学的阐明以及特定实验室分离物的历史。我们的工作起到了锚住H. microstoma基因组的特点,并提供了一个解剖学参考的研究人员需要采用一个模型绦虫系统,使容易获得的所有阶段的生命周期。我们回顾了它的分类,生活史和发展,并简要讨论了基因组和其他模型系统被采用在一个基因组时代的开始,在绦虫学。
Hymenolepis microstoma (Dujardin, 1845) Blanchard, 1891, the mouse bile duct tapeworm, is a rodent/beetle-hosted laboratory model that has been used in research and teaching since its domestication in the 1950s. Recent characterization of its genome has prompted us to describe the specific strain that underpins these data, anchoring its identity and bringing the 150+ year-old original description up-to-date. Morphometric and ultrastructural analyses were carried out on laboratory-reared specimens of the 'Nottingham' strain of Hymenolepis microstoma used for genome characterization. A contemporary description of the species is provided including detailed illustration of adult anatomy and elucidation of its taxonomy and the history of the specific laboratory isolate. Our work acts to anchor the specific strain from which the H. microstoma genome has been characterized and provides an anatomical reference for researchers needing to employ a model tapeworm system that enables easy access to all stages of the life cycle. We review its classification, life history and development, and briefly discuss the genome and other model systems being employed at the beginning of a genomic era in cestodology.
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