Alveolar ridge reduction after tooth extraction in adolescents: an animal study.
Alveolar ridge reduction after tooth extraction in adolescents: an animal study.
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DOI：
10.1016/j.archoralbio.2012.12.013
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发表时间：
2013-07
影响因子：
3
通讯作者：
Gales, Jordan
中科院分区：
文献类型：
--
作者：
Sun, Zongyang;Herring, Susan W.;Tee, Boon Ching;Gales, Jordan
青少年拔牙诱导残余牙槽嵴缩小（RRR）的机制尚不清楚。本研究采用青少年猪模型研究正常和拔牙部位的牙槽骨形态、生长、吸收和功能负荷。将16头3月龄猪分为拔牙后即刻组（IE）和拔牙后6周组（SE）。IE组首先拔除一颗乳牙，随后进行最后的实验，记录拔除部位和对侧非拔除部位在功能（咀嚼）时的咬肌肌肌肌电图和张力。SE组与IE组同样拔牙，保存6周后进行与IE组相同的功能记录。两组均在最终功能记录前10天和3天接受基线（预提取）肌电图和荧光生命染色。在完成最后的功能记录后，立即对动物实施安乐死，收集提取部位和对侧非提取部位的牙槽骨标本，并根据荧光和苏木精和伊红染色的组织学切片分析牙槽骨形态、附着和吸收。对照组（ie -拔牙、ie -未拔牙和se -未拔牙）牙槽嵴在龈部和颊部生长。骨形成以颊面和舌束骨为特征，而吸收以舌面和颊束骨为特征。se提取部位表现出三种主要变化：颊、舌龈嵴会聚，舌束骨对位丧失，整个颊面生长减速。这些变化可能分别是由于牙槽愈合过程中牙嵴生长方向的改变、舌侧对牙弓扩张提供机械刺激的舌侧压力的丧失以及拔牙后初期的咀嚼负荷不足造成的。这些数据表明，青少年RRR的初始阶段是生长改变的产物，而不是吸收的产物，可能是因为提取部位的机械刺激减少。
The mechanism for tooth extraction induced residual alveolar ridge reduction (RRR) during adolescence is poorly understood. This study investigated the alveolar bone morphology, growth, resorption and functional loading at normal and extraction sites using an adolescent pig model. Sixteen 3-month-old pigs were divided into two groups – immediate post-extraction (IE) and 6-week post-extraction (SE). The IE group received an extraction of one deciduous mandibular molar, immediately followed by a final experiment to record masseter muscle EMGs and strains from the buccal surface of the extraction and contralateral non-extraction sites during function (mastication). The SE group was given the same tooth extraction, then kept for 6 weeks before the same final functional recording as the IE group. Both groups also received baseline (pre-extraction) EMGs and fluorescent vital stains 10 and 3 days before the final functional recording. Immediately after the final functional recording, animals were euthanized and alveolar bone specimens from extraction and contralateral non-extraction sites were collected and used to analyze alveolar bone morphology, apposition and resorption based on fluorescent and hematoxylin and eosin stained histological sections. At control sites (IE-extraction, IE-non-extraction and SE-non-extraction), the alveolar ridges grew gingivally and buccally. Bone formation characterized the buccal surface and lingual bundle bone, whereas resorption characterized the lingual surface and buccal bundle bone. The SE-extraction sites showed three major alterations: convergence of the buccal and lingual gingival crests, loss of apposition on the lingual bundle bone, and decelerated growth at the entire buccal surface. These alterations likely resulted from redirected crestal growth as part of the socket healing process, loss of tongue pressure to the lingual side of the teeth which normally provides mechanical stimulation for dental arch expansion, and masticatory underloading during the initial post-extraction period, respectively. These data indicate that the initial phase of RRR in adolescents is a product of modified growth, not resorption, possibly because of decreased mechanical stimulation at the extraction site.
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影响因子：
4.6
作者：
OSTLER, MS;KOKICH, VG
通讯作者：
KOKICH, VG
DOI：
10.1016/s0889-5406(97)80022-4
发表时间：
1997-04-01
影响因子：
3
作者：
Bishara, SE;Jakobsen, JR;Nowak, A
通讯作者：
Nowak, A
影响因子：
2.5
作者：
Diaz, Jaime A.;Bustos, Luis;Fernandez, Belen E.
通讯作者：
Fernandez, Belen E.
影响因子：
2.6
作者：
Gedrange, T;Köbel, C;Harzer, W
通讯作者：
Harzer, W
影响因子：
4.6
作者：
PIETROKO.J;MASSLER, M
通讯作者：
MASSLER, M