Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures.

Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures.
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果蝇胚胎中小齿和毛发的形态发生:肌动蛋白相关蛋白的参与也影响成年结构。

DOI:
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发表时间:
1997
影响因子:
--
通讯作者:
John W. Thatcher
John W. Thatcher
中科院分区:
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文献类型:
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作者:
W. J. Dickinson;John W. Thatcher

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我们寻找在果蝇胚胎中的分割途径下游的形态发生事件中起作用的成分,因此我们检查了影响成体毛发和/或刚毛发育的突变,以确定一个子集,该子集也影响第一龄幼虫角质层上的毛发和绒毛。在调查的23个位点中,有4个位点的突变会导致这些幼虫结构的明显异常,另外两个位点具有更微妙、可变的影响。特别是,分叉和烧焦的突变体产生复杂的等位基因特异性表型。这些基因座编码肌动蛋白相关蛋白,与此信息一致,突变导致肌动蛋白束异常,这些肌动蛋白束支持14-16期胚胎中的新生毛发和致密物。我们认为,这些和其他肌动蛋白相关蛋白之间的相互作用是很重要的,在产生不同的形状的表皮专业化看到幼虫和成人。
We sought components that function in morphogenetic events downstream from the segmentation pathway in Drosophila embryos, so we examined mutations that affect development of adult hairs and/or bristles to identify a subset that also affect hairs and denticles on the cuticle of first instar larvae. Mutations at 4 of 23 loci surveyed cause distinct abnormalities in these larval structures, and two other loci have more subtle, variable effects. In particular, forked and singed mutants produce complex, allele-specific phenotypes. These loci encode actin-associated proteins and, consistent with that information, mutations cause abnormalities in actin bundles that support nascent hairs and denticles in stage 14-16 embryos. We suggest that interactions between these and other actin-associated proteins are important in generating the diverse shapes of the cuticular specializations seen in both larvae and adults.
DOI: 10.1073/pnas.90.11.4937
发表时间: 1993-06-01
影响因子: 11.1
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