Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.
Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.
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DOI：
10.1038/s41569-018-0030-z
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Csiszar A
中科院分区：
文献类型：
--
作者：
Ungvari Z;Tarantini S;Kiss T;Wren JD;Giles CB;Griffin CT;Murfee WL;Pacher P;Csiszar A
衰老是心血管疾病发生的主要危险因素。衰老促进血管病变的一个关键机制是损害内皮健康。与年龄相关的内皮依赖性扩张反应减弱（“内皮功能障碍”）与血管生成过程受损和随后的微循环病理重塑相关，导致组织灌注受损，并加剧老年受试者的功能衰退。本简要概述重点关注衰老过程中内皮细胞发生的细胞、分子和功能变化。它探讨了氧化/硝化应激与影响衰老过程中内皮功能障碍和血管生成受损的保守分子途径之间的联系。这篇综述还推测了如何针对这些病理过程进行治疗。提高对老年患者内皮生物学的了解对于所有心脏病专家都至关重要，因为维持功能正常的内皮对于充足的组织灌注和长期心脏健康至关重要。
Aging is the main risk factor for the development of cardiovascular diseases. A key mechanism by which aging promotes vascular pathologies is by compromising endothelial health. Age-related attenuation of endothelium-dependent dilator responses (‘endothelial dysfunction’) associated with impairment of angiogenic processes and subsequent pathologic remodeling of the microcirculation contribute to compromised tissue perfusion and exacerbates functional decline in older subjects. This brief overview focuses on cellular, molecular, and functional changes that occur in the endothelium during aging. It explores the links between oxidative/nitrative stress and conserved molecular pathways impacting endothelial dysfunction and impaired angiogenesis during aging. This review also speculates on how these pathological processes could be therapeutically targeted. Improved understanding of endothelial biology in older patients is crucial for all cardiologists, as maintenance of a competently functioning endothelium is critical for adequate tissue perfusion and long-term cardiac health.
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