Alcohol disinhibition of behaviors in C. elegans.
Alcohol disinhibition of behaviors in C. elegans.
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DOI：
10.1371/journal.pone.0092965
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Pierce-Shimomura JT
中科院分区：
文献类型：
--
作者：
Topper SM;Aguilar SC;Topper VY;Elbel E;Pierce-Shimomura JT
酒精对生理和行为有各种各样的影响。最广为人知的行为效应之一是去抑制，通常被抑制的行为在醉酒后表现出来。大量的证据表明，酒精诱导的人类抑制解除会影响注意力、言语、性和运动行为。在许多乙醇反应的动物模型中也可以看到类似的行为去抑制，从无脊椎动物到哺乳动物和灵长类动物。在这里，我们描述了几个例子，解除抑制线虫C。优雅的。线虫表现出与多巴胺介导的运动相关的不同行为状态（在陆地上爬行和在水中游泳）。在陆地上，动物自由爬行和进食，但这些行为在水中受到抑制。我们发现，其他行为，包括各种逃避反应，在水中也受到抑制。而酒精非特异性损害运动，喂养，并在陆地上的蠕虫逃逸反应，酒精具体disinhibiting这些行为的蠕虫浸泡在水中。多巴胺信号的损失减轻了摄食行为的去抑制，而D1样多巴胺受体DOP-4的损失损害了乙醇诱导的爬行去抑制。C.强大的遗传学和简单的神经系统。elegans可能有助于揭示保守的分子机制，这些机制是高等动物中酒精诱导的行为抑制解除的基础。
Alcohol has a wide variety of effects on physiology and behavior. One of the most well-recognized behavioral effects is disinhibition, where behaviors that are normally suppressed are displayed following intoxication. A large body of evidence has shown that alcohol-induced disinhibition in humans affects attention, verbal, sexual, and locomotor behaviors. Similar behavioral disinhibition is also seen in many animal models of ethanol response, from invertebrates to mammals and primates. Here we describe several examples of disinhibition in the nematode C. elegans. The nematode displays distinct behavioral states associated with locomotion (crawling on land and swimming in water) that are mediated by dopamine. On land, animals crawl and feed freely, but these behaviors are inhibited in water. We found that additional behaviors, including a variety of escape responses are also inhibited in water. Whereas alcohol non-specifically impaired locomotion, feeding, and escape responses in worms on land, alcohol specifically disinhibited these behaviors in worms immersed in water. Loss of dopamine signaling relieved disinhibition of feeding behavior, while loss of the D1-like dopamine receptor DOP-4 impaired the ethanol-induced disinhibition of crawling. The powerful genetics and simple nervous system of C. elegans may help uncover conserved molecular mechanisms that underlie alcohol-induced disinhibition of behaviors in higher animals.
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影响因子：
2.3
作者：
Gomez, Juan L.;Lewis, Michael J.;Luine, Victoria N.
通讯作者：
Luine, Victoria N.
影响因子：
2.8
作者：
Mitchell, P. H.;Bull, K.;O'Connor, V.
通讯作者：
O'Connor, V.
影响因子：
3.7
作者：
Kong EC;Woo K;Li H;Lebestky T;Mayer N;Sniffen MR;Heberlein U;Bainton RJ;Hirsh J;Wolf FW
通讯作者：
Wolf FW
影响因子：
3.7
作者：
Mitchell P;Mould R;Dillon J;Glautier S;Andrianakis I;James C;Pugh A;Holden-Dye L;O'Connor V
通讯作者：
O'Connor V
DOI：
10.1017/s1461145710000441
发表时间：
2011-03-01
影响因子：
4.8
作者：
Abrahao, Karina Possa;Quadros, Isabel Marian Hartmann;Oliveira Souza-Formigoni, Maria Lucia
通讯作者：
Oliveira Souza-Formigoni, Maria Lucia