Medical imaging of tissue engineering and regenerative medicine constructs.
Medical imaging of tissue engineering and regenerative medicine constructs.
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DOI：
10.1039/d0bm00705f
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发表时间：
2021-01-21
影响因子：
6.6
通讯作者：
Ward SR
中科院分区：
文献类型：
--
作者：
Berry DB ;Englund EK ;Chen S ;Frank LR ;Ward SR
复制组织结构和功能的组织工程和再生医学 (TERM) 策略的进步导致需要对构建体的状态、生物相容性和功能的关键结果测量进行无创评估。基于组织学的方法传统上用于临床前动物实验，但如果要测试 TERM 构建体用于人体的用途，则并不总是可行或实用。为了将这些疗法从台式过渡到临床，必须使用经过严格验证的成像技术，该技术对符合 FDA TERM 构建评估标准的关键结果测量敏感。这篇综述讨论了 TERM 结构的关键结果测量以及可用于评估它们的各种基于临床和研究的成像技术。讨论了这些技术的潜在应用和局限性，以及用于处理、分析和解释生物医学图像的资源。
Advancement of tissue engineering and regenerative medicine (TERM) strategies to replicate tissue structure and function has led to the need for noninvasive assessment of key outcome measures of a construct’s state, biocompatibility, and function. Histology based approaches are traditionally used in preclinical animal experiments, but are not always feasible or practical if a TERM construct is going to be tested for human use. In order to transition these therapies from benchtop to bedside, rigorously validated imaging techniques must be utilized that are sensitive to key outcome measures that fulfill the FDA standards for TERM construct evaluation. This review discusses key outcome measures for TERM constructs and various clinical- and research-based imaging techniques that can be used to assess them. Potential applications and limitations of these techniques are discussed, as well as resources for the processing, analysis, and interpretation of biomedical images.
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影响因子：
19.7
作者：
Barr, Richard G.;Ferraioli, Giovanna;Levine, Deborah
通讯作者：
Levine, Deborah
影响因子：
19.7
作者：
AXEL, L;DOUGHERTY, L
通讯作者：
DOUGHERTY, L
细胞外 pH 值是一种生物标志物，可使用 CEST MRI 检测乳腺癌和肝癌
影响因子：
--
作者：
Chen, Miaomiao;Chen, Chaoying;Wu, Renhua
通讯作者：
Wu, Renhua
影响因子：
4.4
作者：
Chang, Eric Y.;Du, Jiang;Chung, Christine B.
通讯作者：
Chung, Christine B.
影响因子：
3.3
作者：
DETRE, JA;LEIGH, JS;KORETSKY, AP
通讯作者：
KORETSKY, AP