Proposal of a New Classification for Stage III Colorectal Cancer Based on the Number and Ratio of Metastatic Lymph Nodes
Proposal of a New Classification for Stage III Colorectal Cancer Based on the Number and Ratio of Metastatic Lymph Nodes
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基于转移淋巴结数量和比例的III期结直肠癌新分类的提议
DOI：
10.1007/s00268-013-1940-x
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Xiong-Zhi Wu
中科院分区：
文献类型：
--
作者：
Hong-Yan Wang;Rui Cao;Cong Zhu;Xiong-Zhi Wu
BackgroundThe的目的是回顾性研究，以确定目前的分期系统III期结直肠癌（CRC）是适当的，并评估转移淋巴结比率（LNR）在预测患者的预后与III期CRC。MethodsFrom 2000 to 2006 inclusively，245例III期CRC患者进行根治性切除术的价值。后续行动于2012年3月结束。Kaplan-Meier生存曲线和log-rank检验用于生存analysis.ResultsT3N1M0患者的生存时间明显优于IIIB期的其他亚组的患者，与IIIA期疾病的患者相似。最大的生存差异被发现与0.30作为LNR截止点与目前的III期CRC患者。LNR ≤ 0.30的患者生存时间明显优于LNR > 0.30的患者。rN 1包括LNR ≤ 0.30的III期患者，rN 2包括LNR > 0.30的患者。T4 aN 1（rN 2）M0分期的患者的生存时间显着不如T4 aN 1（rN 1）M0分期的患者和类似的患者与IIIC期CRC.ConclusionsWe提出了一种算法，将LNR到目前的美国癌症联合委员会分期系统。其中，T3 N1 M0患者从当前IIIB期排除，并纳入IIIA期组。此外，T4 aN 1（rN 2）M0患者从当前IIIB期组中排除，并纳入IIIC期组。
BackgroundThe objective of this retrospective study was to determine whether the current staging system for stage III colorectal cancer (CRC) is appropriate and to assess the value of the metastatic lymph node ratio (LNR) in predicting the prognosis of patients with stage III CRC.MethodsFrom 2000 to 2006 inclusively, 245 patients with stage III CRC underwent curative resection. The follow-up was closed in March 2012. Kaplan–Meier survival curves and log-rank tests were used for the survival analysis.ResultsSurvival time of patients with T3N1M0 was significantly better than that for patients in other subgroups of stage IIIB and similar to that of patients with stage IIIA disease. The greatest survival difference was found with 0.30 as the LNR cutoff point for patients with current stage III CRC. Survival time of patients with LNR ≤ 0.30 was significantly better than that of those with LNR > 0.30. rN1 included stage III patients with LNR ≤ 0.30, and rN2 included patients with LNR > 0.30. Survival time of patients with T4aN1(rN2)M0 staging was significantly worse than that for patients with T4aN1(rN1)M0 staging and similar to that of patients with stage IIIC CRC.ConclusionsWe propose an algorithm to incorporate LNR into the current American Joint Committee on Cancer staging system. In it the patients with T3N1M0 are excluded from the current stage IIIB and included in the stage IIIA group. Also, patients with T4aN1(rN2)M0 are excluded from the current stage IIIB group and included in the stage IIIC group.
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影响因子：
3.7
作者：
Huh, Jung Wook;Kim, Young Jin;Kim, Hyeong Rok
通讯作者：
Kim, Hyeong Rok
影响因子：
--
作者：
R. Hutter
通讯作者：
R. Hutter
DOI：
10.3393/jksc.2011.27.5.260
发表时间：
2011-10
期刊：
Journal of the Korean Society of Coloproctology
影响因子：
--
作者：
Park YH;Lee JI;Park JK;Jo HJ;Kang WK;An CH
通讯作者：
An CH
影响因子：
3
作者：
Schumacher, Paul;Dineen, Sean;Anthony, Thomas
通讯作者：
Anthony, Thomas
影响因子：
3.7
作者：
Wang, Jiping;Hassett, James M.;Kulaylat, Mahmoud N.
通讯作者：
Kulaylat, Mahmoud N.