Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin.
Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin.
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DOI：
10.1073/pnas.2020398118
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发表时间：
2021-02-02
影响因子：
11.1
通讯作者：
Rogers JA
中科院分区：
文献类型：
--
作者：
Kwon K;Wang H;Lim J;Chun KS;Jang H;Yoo I;Wu D;Chen AJ;Gu CG;Lipschultz L;Kim JU;Kim J;Jeong H;Luan H;Park Y;Su CJ;Ishida Y;Madhvapathy SR;Ikoma A;Kwak JW;Yang DS;Banks A;Xu S;Huang Y;Chang JK;Rogers JA
用于定量监测皮肤水合作用的无线电子设备与我们在临床和家庭环境中对皮肤健康和皮肤结构的理解具有广泛的相关性。在这里，我们提出了一个小型化的远程自动化系统，它可以轻轻地附着在皮肤上，从而产生表皮和真皮层皮肤含水量的定量记录。该系统支持表征皮肤屏障、评估皮肤疾病的严重程度以及评估化妆品和药物疗效的能力，具有高水平的可重复性和对环境的不敏感性。对皮肤病患者的台式和试点研究突出了这些设备的主要特点及其在临床研究和家庭环境中广泛应用的潜力，以指导皮肤疾病的管理。对皮肤水合状态的精确定量测量可以对皮肤健康和皮肤结构和功能产生重要的见解，并与体温调节的基本过程和基础生理学的其他特征具有额外的相关性。现有的测定皮肤含水量的工具利用笨重、坚硬和昂贵的仪器进行替代电评估，这些仪器难以重复使用。最近的替代方案利用软无线设备进行热测量，这些设备可以轻轻地、无创地附着在皮肤表面，但操作范围有限（约1厘米），对细微的环境波动具有高灵敏度。本文介绍了一套克服这些缺点的想法和技术，通过一个小型化的多传感器模块，由芯片上的远程（~ 10米）低功耗蓝牙系统控制，通过图形用户界面与标准智能手机连接，实现热传输特性的高速、强大、远程自动测量。与皮肤表面的软接触，几乎没有用户负担，产生的记录可以定量地与表皮和真皮的水合水平联系起来，使用计算建模技术，具有高水平的可重复性和对环境温度波动的不敏感。系统地研究了类似于人类皮肤、已知水合水平的猪皮和具有临床设备基准的人类受试者的分层结构的聚合物，验证了测量方法和相关的传感器硬件。结果支持表征皮肤屏障功能，评估皮肤疾病的严重程度，以及评估化妆品和药物疗效的能力，可用于诊所或家庭。
Wireless electronics for monitoring of skin hydration in a quantitative fashion have broad relevance to our understanding of dermatological health and skin structure in both clinical and home settings. Here, we present a miniaturized, long-range automated system that adheres gently to the skin to yield quantitative recordings of skin water content for both epidermis and dermis. This system supports capabilities in characterizing skin barrier, assessing severity of skin diseases, and evaluating cosmetic and medication efficacy, with high levels of repeatability and insensitivity to ambient. Benchtop and pilot studies on patients with skin diseases highlight key features of these devices and their potential for broad utility in clinical research and in home settings to guide the management of disorders of the skin. Precise, quantitative measurements of the hydration status of skin can yield important insights into dermatological health and skin structure and function, with additional relevance to essential processes of thermoregulation and other features of basic physiology. Existing tools for determining skin water content exploit surrogate electrical assessments performed with bulky, rigid, and expensive instruments that are difficult to use in a repeatable manner. Recent alternatives exploit thermal measurements using soft wireless devices that adhere gently and noninvasively to the surface of the skin, but with limited operating range (∼1 cm) and high sensitivity to subtle environmental fluctuations. This paper introduces a set of ideas and technologies that overcome these drawbacks to enable high-speed, robust, long-range automated measurements of thermal transport properties via a miniaturized, multisensor module controlled by a long-range (∼10 m) Bluetooth Low Energy system on a chip, with a graphical user interface to standard smartphones. Soft contact to the surface of the skin, with almost zero user burden, yields recordings that can be quantitatively connected to hydration levels of both the epidermis and dermis, using computational modeling techniques, with high levels of repeatability and insensitivity to ambient fluctuations in temperature. Systematic studies of polymers in layered configurations similar to those of human skin, of porcine skin with known levels of hydration, and of human subjects with benchmarks against clinical devices validate the measurement approach and associated sensor hardware. The results support capabilities in characterizing skin barrier function, assessing severity of skin diseases, and evaluating cosmetic and medication efficacy, for use in the clinic or in the home.
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影响因子：
2.4
作者：
DeSanti, Leslie
通讯作者：
DeSanti, Leslie
影响因子：
2.2
作者：
du Plessis, Johan;Stefaniak, Aleksandr;Holness, Linn
通讯作者：
Holness, Linn
影响因子：
5.5
作者：
PINNAGODA, J;TUPKER, RA;SERUP, J
通讯作者：
SERUP, J
影响因子：
3.3
作者：
Qassem, Meha;Kyriacou, Panayiotis
通讯作者：
Kyriacou, Panayiotis
DOI：
10.1159/000446756
发表时间：
2016-01-01
期刊：
Perspiration Research
影响因子：
--
作者：
Shiohara, Tetsuo;Sato, Yohei;Mizukawa, Yoshiko
通讯作者：
Mizukawa, Yoshiko