Morbidity and mortality associated with the restrictive spirometric pattern: a longitudinal study.
Morbidity and mortality associated with the restrictive spirometric pattern: a longitudinal study.
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DOI：
10.1136/thx.2009.126052
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发表时间：
2010-06
期刊：
影响因子：
10
通讯作者：
Martinez FD
中科院分区：
文献类型：
--
作者：
Guerra S;Sherrill DL;Venker C;Ceccato CM;Halonen M;Martinez FD
最近的研究表明，用单一肺活量测定法评估限制性模式与增加发病率和死亡率有关。在这项研究中，我们试图确定有反复或不一致限制性肺活量测定模式的受试者的人口统计学、临床和死亡率特征。我们分析了以人群为基础的TESAOD研究中2048名成年参与者的数据。在入院调查(1972年)和直到1996年的11次后续调查中，评估了正常(FEV1/FVC比率≥预测为70%，FVC≥预测为80%)、限制性(FEV1/FVC≥预测为70%和FVC；80%)和梗阻(FEV1/FVC<；70%)模式。在登记时测量了人口统计学和临床特征，并评估了截至2005年1月的生命状况和死亡原因。总体而言，12%的参与者在登记时有限制性的肺活量模式。与阻塞组的受试者相比，他们不太可能是男性，不太可能吸烟和患有哮喘，而且IgE水平较低。在登记时有限制性模式的受试者中，38%的受试者在随访期间发展为梗阻性模式。其余62%的患者要么复发(限制性模式≥50%的随访调查)，要么不一致(限制性模式&50%的随访调查)纵向限制性模式。反复和不一致限制性分组增加了全因(adjHR：1.7，1.3-2.3和1.9，1.4-2.6)、心脏病(2.0，1.3-3.1和2.7，1.7-4.3)、中风(2.4，0.9-6.3；3.5，1.2-9.8)和糖尿病(8.0，2.9-21.8；6.0，1.9-19.2)的死亡风险。限制性肺活量测定模式确定了一种与阻塞性肺疾病相区别的肺部疾病，并与威胁生命的并存疾病的风险增加有关。
Recent studies have suggested that a restrictive pattern assessed with a single spirometry is associated with increased morbidity and mortality. In this study, we sought to determine demographic, clinical, and mortality profiles of subjects with either a recurrent or inconsistent restrictive spirometric pattern assessed prospectively. We analyzed data from 2048 adult participants in the population-based TESAOD study. Normal (FEV1/FVC ratio≥70% and FVC≥80% predicted), restrictive (FEV1/FVC≥70% and FVC<80% predicted), and obstructive (FEV1/FVC<70%) patterns were assessed at the enrollment survey (1972) and in eleven subsequent follow-up surveys up to 1996. Demographic and clinical characteristics were measured at enrollment and vital status and cause of death were assessed as of January 2005. Overall, 12% of participants had a restrictive spirometric pattern at enrollment. They were less likely to be males, to smoke and to have asthma, and had lower IgE levels as compared with subjects in the obstructive group. Among subjects with a restrictive pattern at enrollment, 38% developed an obstructive pattern during the follow-up. The remaining 62% had either a recurrent (restrictive pattern≥50% of follow-up surveys) or inconsistent (restrictive pattern<50% of follow-up surveys) longitudinal restrictive pattern. The recurrent and inconsistent restrictive groups had increased mortality risk for all-cause (adjHR: 1.7, 1.3–2.3; and 1.9, 1.4–2.6; respectively), heart disease (2.0, 1.3–3.1; and 2.7, 1.7–4.3), stroke (2.4, 0.9–6.3; and 3.5, 1.2–9.8), and diabetes (8.0, 2.9–21.8; and 6.0, 1.9–19.2). The restrictive spirometric pattern identifies a pulmonary condition that is distinguishable from obstructive lung disease and associated with increased risk of life-threatening co-morbidities.
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影响因子：
24.3
作者：
Mannino, D. M.;Thorn, D.;Holguin, F.
通讯作者：
Holguin, F.
影响因子：
120.7
作者：
Jemal, A;Ward, E;Thun, M
通讯作者：
Thun, M
影响因子：
5
作者：
LEBOWITZ, MD;KNUDSON, RJ;BURROWS, B
通讯作者：
BURROWS, B
影响因子：
39.2
作者：
ASHLEY, F;KANNEL, WB;MASSON, R
通讯作者：
MASSON, R
DOI：
10.1164/arrd.1983.128.3.501
发表时间：
1983-01-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
RAY, CS;SUE, DY;WASSERMAN, K
通讯作者：
WASSERMAN, K