Chinese herbs in treatment of influenza: a randomized, double-blind, placebo-controlled trial.
Chinese herbs in treatment of influenza: a randomized, double-blind, placebo-controlled trial.
复制标题
中药治疗流感：一项随机、双盲、安慰剂对照试验
DOI：
10.1016/j.rmed.2010.05.015
复制
发表时间：
2010-09
影响因子：
4.3
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Wang L;Zhang RM;Liu GY;Wei BL;Wang Y;Cai HY;Li FS;Xu YL;Zheng SP;Wang G
目的：观察中药安体卫方治疗流感的疗效和安全性。在一项多中心、随机、双盲、安慰剂对照的试验中，我们招募了480名年龄在18岁至65岁之间的成年人，年龄在流感样症状出现的36小时内。确诊的流感患者有225人。符合条件的患者被随机分配为每天两次服用6克安替维组(n=360)或安慰剂(n=120)，为期三天。所有患者在治疗过程中将体温和症状记录在日记卡上。在流感样人群和流感确诊人群中进行了分析。与安慰剂相比，在流感样人群和流感确诊人群中，安替维使患者的恢复率提高了17%(P<；(0.001)，并将以症状评分中位数衡量的疾病严重程度降低了50%(P<；(0.001))。与安慰剂相比，确诊为流感的患者报告说，与安慰剂相比，服用安替维一天后，发烧(P=0.002)、咳嗽(P=0.023)和咳痰(P=0.004)的严重程度有所减轻。安替维组和安慰剂组的不良反应情况相似。安替维治疗成人自然流感感染有效，耐受性好。安替维代表了流感管理中一种具有临床价值的干预措施。
To investigate the efficacy and safety of Antiwei, a traditional Chinese prescription, in the treatment of influenza. In a multi-center, randomized, double-blind, placebo-controlled trial, we recruited 480 adults aged 18 to 65 years within 36 h of onset of influenza-like symptoms. There were 225 patients with confirmed influenza. Eligible patients were randomly assigned 6 g of Antiwei (n = 360) or placebo (n = 120) twice daily for three days. All patients recorded their temperature and symptoms on diary cards during treatment. Analyses were performed in both the influenza-like population and the influenza-confirmed population. Antiwei increased patients’ recovery by 17% (P < 0.001), and reduced the severity of illness measured by the median symptom score by 50% (P < 0.001) in both the influenza-like and the influenza-confirmed populations, compared to placebo. The influenza-confirmed patients reported reductions in the severity of fever (P = 0.002), cough (P = 0.023) and expectoration (P = 0.004) after one-day of treatment with Antiwei, compared to placebo. The adverse event profiles were similar for Antiwei and placebo. Antiwei was effective and well tolerated in treatment of natural influenza infection in adults. Antiwei represents a clinically valuable intervention in the management of influenza.
登录
查看更多内容
影响因子：
4.3
作者：
Wu T;Yang X;Zeng X;Poole P
通讯作者：
Poole P
DOI：
10.1126/science.1177373
发表时间：
2009-10-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Yang Y;Sugimoto JD;Halloran ME;Basta NE;Chao DL;Matrajt L;Potter G;Kenah E;Longini IM Jr
通讯作者：
Longini IM Jr
影响因子：
5.7
作者：
Mehendale, SR;Bauer, BA;Yuan, CS
通讯作者：
Yuan, CS
DOI：
10.1093/ecam/nem035
发表时间：
2008-09
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Hsu CH;Hwang KC;Chao CL;Chang SG;Ho MS;Lin JG;Chang HH;Kao ST;Chen YM;Chou P
通讯作者：
Chou P
影响因子：
158.5
作者：
Hayden, FG;Osterhaus, ADME;Wightman, K
通讯作者：
Wightman, K