An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study.
An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study.
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DOI：
10.1093/ecam/nem035
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Chou P
中科院分区：
文献类型：
--
作者：
Hsu CH;Hwang KC;Chao CL;Chang SG;Ho MS;Lin JG;Chang HH;Kao ST;Chen YM;Chou P
天然草药（NHM）数千年来一直被用来控制传染病。鉴于NHM对SARS可能的有益作用，我们进行了这项研究，以检查NHM作为SARS或SARS样传染病的辅助治疗是否有任何益处。这是一项随机、双盲、安慰剂对照试验。28例患者符合WHO入选标准和我们的排除标准。所有入选患者均接受西医常规治疗。患者被随机分配到三个补充治疗组之一：NHM A（A组，n = 9）、NHM B（B组，n = 9）或安慰剂（C组，n = 10）。每例患者每1 ~ 2天进行一次胸部X线检查。阅读放射科医生根据每个肺野（左右肺各3个肺野）浸润的严重程度，采用标准的0-3评分系统（0：无浸润; 1：局灶性模糊或甚至小斑片状病变; 2：磨玻璃样影; 3：肺叶实变）。主要结果测量是胸部放射学评分（IRS）的改善和改善持续时间（天数）（DI）。安慰剂组1例患者死亡。与安慰剂组（11.2 ± 4.9）相比，NHM A组患者出现改善所需的天数较少（6.7 ± 1.8），具有统计学意义（P = 0.04）。这些病例太少，无法得出结论，初步观察似乎表明NHM在非危重患者中似乎是安全的，临床试验在大流行爆发的背景下是可行的。
Natural herbal medicine (NHM) has been used to control infectious diseases for thousands of years. In view of the possible beneficial effect of NHM on SARS, we conducted this study to examine whether NHM is of any benefit as a supplementary treatment of SARS or SARS-like infectious disease. This was a randomized, double-blind, placebo-controlled trial. Twenty-eight patients fulfilled the WHO inclusion criteria and our exclusion criteria. All enrolled patients received routine western-medicine treatment. Patients were randomly allocated to one of the three supplementary treatment groups: NHM A (Group A, n = 9) NHM B (Group B, n = 9) or placebo (Group C, n = 10). Chest X-ray was done every 1 or 2 days for every patient. Reading radiologists use a standard 0–3 scoring system (0: no infiltration; 1: focal haziness or even small patchy lesion; 2: ground glass picture; 3: lobar consolidation) according to the severity of infiltration in each lung field (three lung fields in both right and left lungs). The main outcome measurements were the improving chest radiographic scores (IRS) and the duration (days) till improvement (DI). One patient from the placebo group passed away. Patients from NHM A took less days before showing improvement (6.7 ± 1.8) compared with placebo group (11.2 ± 4.9), which showed statistical significance (P = 0.04). The cases were too few to be conclusive, the initial observations seem to indicate NHM appears to be safe in non-criticallly ill patients and clinical trials are feasible in the setting of pandemic outbreaks.
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DOI：
10.1016/s0140-6736(03)13077-2
发表时间：
2003-04-19
期刊：
Lancet (London, England)
影响因子：
--
作者：
Peiris JS;Lai ST;Poon LL;Guan Y;Yam LY;Lim W;Nicholls J;Yee WK;Yan WW;Cheung MT;Cheng VC;Chan KH;Tsang DN;Yung RW;Ng TK;Yuen KY;SARS study group
通讯作者：
SARS study group
DOI：
10.1016/s0140-6736(03)13967-0
发表时间：
2003-07-26
期刊：
Lancet (London, England)
影响因子：
--
作者：
Kuiken T;Fouchier RA;Schutten M;Rimmelzwaan GF;van Amerongen G;van Riel D;Laman JD;de Jong T;van Doornum G;Lim W;Ling AE;Chan PK;Tam JS;Zambon MC;Gopal R;Drosten C;van der Werf S;Escriou N;Manuguerra JC;Stöhr K;Peiris JS;Osterhaus AD
通讯作者：
Osterhaus AD
DOI：
10.1016/s0140-6736(03)13364-8
发表时间：
2003-05-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hon KL;Leung CW;Cheng WT;Chan PK;Chu WC;Kwan YW;Li AM;Fong NC;Ng PC;Chiu MC;Li CK;Tam JS;Fok TF
通讯作者：
Fok TF
影响因子：
6.4
作者：
Boivin, G;Abed, Y;Anderson, LJ
通讯作者：
Anderson, LJ
影响因子：
5.6
作者：
Nakajima, A;Ishida, T;Takeuchi, M
通讯作者：
Takeuchi, M