The transmissibility and control of pandemic influenza A (H1N1) virus.

The transmissibility and control of pandemic influenza A (H1N1) virus.
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DOI:
10.1126/science.1177373
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发表时间:
2009-10-30
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Longini IM Jr
Longini IM Jr
中科院分区:
其他
文献类型:
--
作者:
Yang Y;Sugimoto JD;Halloran ME;Basta NE;Chao DL;Matrajt L;Potter G;Kenah E;Longini IM Jr

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2009年甲型H1N1流感大流行(H1N1大流行)正在全球蔓延。它已经成为南半球的主要菌株,那里的流感季节正在进行中。在此,基于美国报告的病例群,我们估计H1N1大流行的家庭继发性发作率为27.3%(95%CI:12.2%-50.5%)。从学校爆发,我们估计一个学生感染2.4(95% CI:1.8-3.2)在学校内的其他儿童。我们估计的基本繁殖数,R 0,范围为1.3-1.7和世代间隔范围为2.6-3.2天。我们使用一个模拟模型来评估2009年秋季美国疫苗接种策略的有效性。如果疫苗能够尽快上市,儿童接种疫苗,然后是成人接种疫苗,总覆盖率达到70%,此外还有高风险和必要的劳动力群体,可以减轻严重的流行病。
Pandemic influenza A (H1N1) 2009 (pandemic H1N1) is spreading throughout the planet. It has become the dominant strain in the southern hemisphere, where the influenza season is underway. Here, based on reported case clusters in the USA, we estimate the household secondary attack rate for pandemic H1N1 to be 27.3% (95% CI: 12.2%–50.5%). From a school outbreak, we estimate a school child infects 2.4 (95% CI: 1.8–3.2) other children within the school. We estimate the basic reproductive number, R0, to range from 1.3–1.7 and the generation interval to range from 2.6–3.2 days. We use a simulation model to evaluate the effectiveness of vaccination strategies in the USA for the Fall, 2009. If vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high risk and essential workforce groups, could mitigate a severe epidemic.
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