Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease.
Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease.
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DOI：
10.4061/2011/247467
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发表时间：
2011-02-15
期刊：
影响因子：
--
通讯作者：
Farooqui AA
中科院分区：
文献类型：
--
作者：
Farooqui T;Farooqui AA
帕金森病是一种病因不明的神经退行性运动障碍。帕金森病的特点是黑质多巴胺能神经元进行性丢失，纹状体多巴胺耗竭，线粒体和蛋白酶体功能异常，α-突触核蛋白积聚，可能与病理和临床异常密切相关。越来越多的证据表明，氧化应激和炎症可能在帕金森病的发病机制中起着基础性作用。氧化应激的特征是活性氧物种(ROS)的增加和谷胱甘肽的耗竭。氧化应激的脂质介体包括4-羟基壬烯醛、异前列腺素、异呋喃、异酮、神经前列腺素和神经呋喃。神经炎症的特征是激活的小胶质细胞产生促炎细胞因子，如肿瘤坏死因子-α和白介素1-β。前炎性脂质介质包括前列腺素和血小板活化因子，与细胞因子一起在介导帕金森病进行性神经变性中可能起重要作用。
Parkinson's disease (PD) is a neurodegenerative movement disorder of unknown etiology. PD is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, depletion of dopamine in the striatum, abnormal mitochondrial and proteasomal functions, and accumulation of α-synuclein that may be closely associated with pathological and clinical abnormalities. Increasing evidence indicates that both oxidative stress and inflammation may play a fundamental role in the pathogenesis of PD. Oxidative stress is characterized by increase in reactive oxygen species (ROS) and depletion of glutathione. Lipid mediators for oxidative stress include 4-hydroxynonenal, isoprostanes, isofurans, isoketals, neuroprostanes, and neurofurans. Neuroinflammation is characterized by activated microglial cells that generate proinflammatory cytokines, such as TNF-α and IL-1β. Proinflammatory lipid mediators include prostaglandins and platelet activating factor, together with cytokines may play a prominent role in mediating the progressive neurodegeneration in PD.
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