Epidermal growth factor receptor derived peptide vaccination to prevent lung adenocarcinoma formation: An in vivo study in a murine model of EGFR mutant lung cancer.
Epidermal growth factor receptor derived peptide vaccination to prevent lung adenocarcinoma formation: An in vivo study in a murine model of EGFR mutant lung cancer.
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DOI：
10.1002/mc.22405
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发表时间：
2016-11
影响因子：
4.6
通讯作者：
You M
中科院分区：
文献类型：
--
作者：
Ebben JD;Lubet RA;Gad E;Disis ML;You M
预防疾病的能力是医学的圣杯。几十年来，人们一直在努力将传染病疫苗接种的成功扩展到癌症。在某些情况下，针对病毒（典型的是 HPV）的预防性疫苗接种已成功预防肿瘤发生，并将在未来几十年对公众健康产生重大影响。然而，大多数癌症的发生是宿主体内基因突变或非病毒环境暴露的结果。我们提出了令人信服的证据，证明针对过度表达的自体肿瘤癌蛋白的疫苗接种有可能预防肿瘤的发展。在 EGFR 驱动的肺癌小鼠模型中，在预防性环境中使用多肽疫苗进行表皮生长因子受体 (EGFR) 疫苗接种，可将 EGFR 驱动的肺癌发生率降低 76.4%。我们还证明，抗 EGFR 疫苗接种可以促进体内强大免疫反应的发展。这项研究首次提供了概念证明，即在肺癌预防环境中使用肽疫苗接种来靶向肿瘤驱动因素可以抑制肿瘤发生，并可能为在 EGFR 突变性疾病高度流行的人群中制定针对 EGFR 疫苗接种的策略提供有用的临床见解。
The ability to prevent disease is the holy grail of medicine. For decades, efforts have been made to extend the successes seen with vaccination against infectious diseases to cancer. In some instances, preventive vaccination against viruses (prototypically HPV) has successfully prevented tumorigenesis and will make a major impact on public health in the decades to come. However, the majority of cancers that arise are a result of genetic mutation within the host, or non-viral environmental exposures. We present compelling evidence that vaccination against an overexpressed self-tumor oncoprotein has the potential to prevent tumor development. Vaccination against the Epidermal Growth Factor Receptor (EGFR) using a multipeptide vaccine in a preventive setting decreased EGFR-driven lung carcinogenesis by 76.4% in a mouse model of EGFR-driven lung cancer. We also demonstrate that anti-EGFR vaccination primes the development of a robust immune response in vivo. This study provides proof of concept for the first time that targeting tumor drivers in a preventive setting in lung cancer using peptide vaccination can inhibit tumorigenesis and may provide useful clinical insights into the development of strategies to vaccinate against EGFR in populations that where EGFR-mutant disease is highly prevalent.
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影响因子：
3.7
作者：
Putila J;Guo NL
通讯作者：
Guo NL
影响因子：
1
作者：
Lubin, JH
通讯作者：
Lubin, JH
影响因子：
5.4
作者：
Hystad, Perry;Demers, Paul A.;Brauer, Michael
通讯作者：
Brauer, Michael
亚洲晚期非小细胞腺癌组织学肺癌患者 EGFR 突变的前瞻性分子流行病学研究 (PIONEER)。
DOI：
10.1097/jto.0000000000000033
发表时间：
2014-02
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Shi Y;Au JS;Thongprasert S;Srinivasan S;Tsai CM;Khoa MT;Heeroma K;Itoh Y;Cornelio G;Yang PC
通讯作者：
Yang PC
DOI：
10.1164/rccm.200502-235pp
发表时间：
2006-01-01
影响因子：
24.7
作者：
Schwartz, AG;Ruckdeschel, JC
通讯作者：
Ruckdeschel, JC