Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
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DOI：
10.1186/ar3072
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发表时间：
2010
影响因子：
4.9
通讯作者：
Beltrán J
中科院分区：
文献类型：
--
作者：
Fayed N;Garcia-Campayo J;Magallón R;Andrés-Bergareche H;Luciano JV;Andres E;Beltrán J
本研究的目的是调查单体素 (SV) 质子磁共振波谱 (MRS)、扩散加权成像 (DWI) 和扩散张量成像 (DTI) 是否检测到纤维肌痛 (FM) 患者和健康对照之间的差异。我们还寻找神经影像异常与神经心理学变量之间的相关性。对 10 名 FM 患者和 10 名性别和年龄匹配的对照受试者进行了研究。对已知与疼痛处理相关的大脑区域进行了神经心理学检查、DWI、DTI 和质子 MRS。与健康对照相比，FM 患者的谷氨酸 + 谷氨酰胺 (Glx) 水平显着较高（平均值 ± SD，10.71 ± 0.50 任意机构单位 vs 9.89 ± 1.04；P = 0.049），并且谷氨酸 + 谷氨酰胺/肌酸 (Glx/Cr) 比率较高（1.90 ± 0.12 vs 1.72 ± 0.23；P = 0.034）位于后回。 FM 患者左右海马肌醇 (Ins) 水平显着较低（分别为 4.49 ± 0.74 与 5.17 ± 0.62；P = 0.008 和 4.91 ± 0.85 与 6.09 ± 0.78；P = 0.004）。在 FM 患者中，左侧感觉运动区 (P = 0.05) 和左侧海马 (P = 0.002) 肌醇/肌酸 (Ins/Cr) 比率降低，左侧海马胆碱 (P = 0.019) 和 N-乙酰天冬氨酸 + N-乙酰天冬氨酰谷氨酸 (NAA + NAG) (P = 0.034) 水平较低。观察到抑郁、疼痛和整体功能与后回 Glx 水平和 Glx/Cr 比率之间的显着相关性。后回 Glx 可能是 FM 的病理因素。海马功能障碍可能是 FM 抑郁症状的部分原因。需要更大样本的额外研究来证实这些初步数据。
The purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences between fibromyalgia (FM) patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables. Ten patients with FM and 10 gender- and age-matched control subjects were studied. A neuropsychological examination, DWI, DTI, and proton MRS were performed on the brain areas known to be associated with pain processing. Compared with healthy controls, FM patients had significantly higher levels of glutamate + glutamine (Glx) (mean ± SD, 10.71 ± 0.50 arbitrary institutional units versus 9.89 ± 1.04; P = 0.049) and higher glutamate + glutamine/creatine (Glx/Cr) ratios (1.90 ± 0.12 versus 1.72 ± 0.23; P = 0.034) in the posterior gyrus. Myoinositol (Ins) levels of the right and left hippocampi were significantly lower in FM patients (4.49 ± 0.74 versus 5.17 ± 0.62; P = 0.008 and 4.91 ± 0.85 versus 6.09 ± 0.78; P = 0.004, respectively). In FM patients, decreased myoinositol/creatine (Ins/Cr) ratios were found in the left sensorimotor area (P = 0.05) and the left hippocampus (P = 0.002) and lower levels of choline (P = 0.019) and N-acetyl aspartate + N-acetyl aspartyl glutamate (NAA + NAG) (P = 0.034) in the left hippocampus. Significant correlations between depression, pain, and global function and the posterior gyrus Glx levels and Glx/Cr ratios were observed. Glx within the posterior gyrus could be a pathologic factor in FM. Hippocampal dysfunction may be partially responsible for the depressive symptoms of FM. Additional studies with larger samples are required to confirm these preliminary data.
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影响因子：
1.9
作者：
Fayed, Nicolas;Davila, Jorge;Castillo, Julio
通讯作者：
Castillo, Julio
影响因子：
3.6
作者：
Gormsen, Lise;Rosenberg, Raben;Jensen, Troels S.
通讯作者：
Jensen, Troels S.
影响因子：
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作者：
Gracely, RH;Petzke, F;Clauw, DJ
通讯作者：
Clauw, DJ
影响因子：
7.4
作者：
Hadjipavlou, George;Dunckley, Paul;Tracey, Irene
通讯作者：
Tracey, Irene
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR