Improved biocompatibility of Zn-Ag-based stent materials by microstructure refinement.
Improved biocompatibility of Zn-Ag-based stent materials by microstructure refinement.
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DOI：
10.1016/j.actbio.2022.03.047
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发表时间：
2022-06
影响因子：
9.7
通讯作者：
Goldman J
中科院分区：
文献类型：
--
作者：
Guillory RJ 2nd;Mostaed E;Oliver AA;Morath LM;Earley EJ;Flom KL;Kolesar TM;Mostaed A;Summers HD;Kwesiga MP;Drelich JW;Carlson KD;Dragomir-Daescu D;Goldman J
生物可吸收锌基医用合金的冶金工程将大大受益于材料性能和生物反应之间的关系的澄清。在这里，我们调查的生物相容性的三个锌基银（Ag）含合金，从二元到五元合金系统。选定的二元和五元Zn-Ag基合金进行固溶处理（ST），以增加富Ag相的溶解度内的Zn块体基质，产生两种不同的微观结构（一个没有ST和ST的不同的一个）具有相同的元素组成。本实验设计旨在阐明Zn-Ag系统的元素分布/微观结构与生物相容性之间的关系。我们发现，五元合金系统（Zn-4Ag-0.8Cu-0.6Mn-0.15Zr）的性能显着更好，在组织形态计量学方面，比任何合金系统，我们已经评估到目前为止。此外，当进行固溶处理以提高强度和延展性并减少富银相的含量时，五元合金的生物相容性进一步提高。体内植入物的体外腐蚀试验和金相分析表明，溶液处理合金的腐蚀模式更均匀。我们得出结论，锌银合金可以通过合金化工程，以大大减少新生内膜生长。通过将AgZn 3沉淀物溶解在Zn基质中以改善腐蚀均匀性，可以进一步增强对新生内膜生长的积极作用。这些研究结果表明，新生内膜形成细胞可以通过可降解锌基植入材料中的元素添加和微观结构变化来调节。
The metallurgical engineering of bioresorbable zinc (Zn)-based medical alloys would greatly benefit from clarification of the relationships between material properties and biological responses. Here we investigate the biocompatibility of three Zn-based silver (Ag)-containing alloys, ranging from binary to quinary alloy systems. Selected binary and quinary Zn-Ag-based alloys underwent solution treatment (ST) to increase the solubility of Ag-rich phases within the Zn bulk matrix, yielding two different microstructures (one without ST and a different one with ST) with the same elemental composition. This experimental design was intended to clarify the relationship between elemental profile/microstructure and biocompatibility for the Zn-Ag system. We found that the quinary alloy system (Zn-4Ag-0.8Cu-0.6Mn-0.15Zr) performed significantly better, in terms of histomorphometry, than any alloy system we have evaluated to date. Furthermore, when solution treated to increase strength and ductility and reduce the fraction of Ag-rich phases, the quinary alloy biocompatibility further improved. In vitro corrosion testing and metallographic analysis of in vivo implants demonstrated a more uniform mode of corrosion for the solution treated alloy. We conclude that Zn-Ag alloys can be engineered through alloying to substantially reduce neointimal growth. The positive effect on neointimal growth can be further enhanced by dissolving the AgZn3 precipitates in the Zn matrix to improve the corrosion uniformity. These findings demonstrate that neointimal-forming cells can be regulated by elemental additions and microstructural changes in degradable Zn-based implant materials.
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影响因子：
4.7
作者：
Oliver AA;Guillory RJ 2nd;Flom KL;Morath LM;Kolesar TM;Mostaed E;Sikora-Jasinska M;Drelich JW;Goldman J
通讯作者：
Goldman J
影响因子：
3.9
作者：
Mudunkotuwa, Imali A.;Rupasinghe, Thilini;Grassian, Vicki H.
通讯作者：
Grassian, Vicki H.
DOI：
10.1016/j.msec.2015.07.022
发表时间：
2015-11-01
期刊：
Materials science & engineering. C, Materials for biological applications
影响因子：
--
作者：
Bowen PK;Guillory RJ 2nd;Shearier ER;Seitz JM;Drelich J;Bocks M;Zhao F;Goldman J
通讯作者：
Goldman J
影响因子：
9.7
作者：
Mostaed, Ehsan;Sikora-Jasinska, Malgorzata;Drelich, Jaroslaw W.
通讯作者：
Drelich, Jaroslaw W.
DOI：
10.1016/j.jmbbm.2016.03.018
发表时间：
2016-07-01
影响因子：
3.9
作者：
Mostaed, E.;Sikora-Jasinska, M.;Vedani, M.
通讯作者：
Vedani, M.