Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model.
Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model.
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DOI：
10.1038/s41467-021-22580-8
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发表时间：
2021-04-16
影响因子：
16.6
通讯作者：
Jarvis MA
中科院分区：
文献类型：
--
作者：
Rosenke K;Hansen F;Schwarz B;Feldmann F;Haddock E;Rosenke R;Barbian K;Meade-White K;Okumura A;Leventhal S;Hawman DW;Ricotta E;Bosio CM;Martens C;Saturday G;Feldmann H;Jarvis MA
COVID-19疫情在全球多个地区有增无减。一种有效的抗SARS-CoV-2的抗病毒药物，可以在高风险暴露后口服使用，这将对控制COVID-19大流行有重大益处。在此，我们表明，MK-4482，口服给药的核苷类似物，抑制SARS-CoV-2复制在叙利亚仓鼠模型。在高风险暴露模型中，当在感染前12小时或感染后12小时开始给药时，在动物中观察到MK-4482对SARS-CoV-2复制的抑制作用。这些数据支持MK-4482在高风险暴露后控制人类SARS-CoV-2感染以及治疗COVID-19患者的潜在效用。虽然预防SARS-CoV-2感染的疫苗已获得批准，但目前还没有适合用于预防SARS-CoV-2高风险暴露的药物。在此，Rosenke等人提供了口服MK-4482（一种核苷类似物）抑制叙利亚仓鼠模型中SARS-CoV-2复制的证据。
The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhibitory effect of MK-4482 on SARS-CoV-2 replication is observed in animals when the drug is administered either beginning 12 h before or 12 h following infection in a high-risk exposure model. These data support the potential utility of MK-4482 to control SARS-CoV-2 infection in humans following high-risk exposure as well as for treatment of COVID-19 patients. While vaccines protecting against SARS-CoV-2 infection are approved, currently, there are no drugs suitable for high-risk exposure use against SARS-CoV-2. Here, Rosenke et al. provide evidence that orally delivered MK-4482, a nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model.
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影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
DOI：
10.1073/pnas.2014441117
发表时间：
2020-10-27
影响因子：
11.1
作者：
Kaptein SJF;Jacobs S;Langendries L;Seldeslachts L;Ter Horst S;Liesenborghs L;Hens B;Vergote V;Heylen E;Barthelemy K;Maas E;De Keyzer C;Bervoets L;Rymenants J;Van Buyten T;Zhang X;Abdelnabi R;Pang J;Williams R;Thibaut HJ;Dallmeier K;Boudewijns R;Wouters J;Augustijns P;Verougstraete N;Cawthorne C;Breuer J;Solas C;Weynand B;Annaert P;Spriet I;Vande Velde G;Neyts J;Rocha-Pereira J;Delang L
通讯作者：
Delang L
影响因子：
3.3
作者：
Feldmann, Friederike;Shupert, W. Lesley;Feldmann, Heinz
通讯作者：
Feldmann, Heinz
影响因子：
4.9
作者：
Ehteshami, Maryam;Tao, Sijia;Schinazi, Raymond F.
通讯作者：
Schinazi, Raymond F.
影响因子：
1.8
作者：
Du, Yan;Li, Yin-jie;Tang, Dao-quan
通讯作者：
Tang, Dao-quan