MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells.
MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells.
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髓鞘呈递给中枢神经系统（CNS）内的T细胞维持多发性硬化（MS）中的炎症。CD 4+和CD 8 + T细胞有助于MS;然而，仅鉴定了将髓磷脂呈递给CD 4 + T细胞的细胞。我们发现，MHC I类限制性髓鞘碱性蛋白（MBP）提出的少突胶质细胞和交叉提出的提示树突状细胞（DC）在实验性自身免疫性脑脊髓炎（EAE），MS的动物模型由CD 4 + T细胞启动。Tip-DCs离体激活幼稚和效应CD 8 + T细胞，并且在CD 4 + T细胞诱导的EAE期间，幼稚MBP特异性CD 8 + T细胞在中枢神经系统内被激活。这些结果表明，CD 4 + T细胞介导的CNS自身免疫导致决定簇扩散到能够直接识别少突胶质细胞的髓鞘特异性CD 8 + T细胞。
Myelin presentation to T cells within the central nervous system (CNS) sustains inflammation in multiple sclerosis (MS). CD4+ and CD8+ T cells contribute to MS; however, only cells that present myelin to CD4+ T cells have been identified. We show that MHC class I-restricted myelin basic protein (MBP) was presented by oligodendrocytes and cross-presented by Tip-dendritic cells (DCs) during experimental autoimmune encephalomyelitis (EAE), an animal model of MS initiated by CD4+ T cells. Tip-DCs activated naïve and effector CD8+ T cells ex vivo, and naïve MBP-specific CD8+ T cells were activated within the CNS during CD4+ T cell-induced EAE. These results demonstrate that CD4+ T cell-mediated CNS autoimmunity leads to determinant spreading to myelin-specific CD8+ T cells that are capable of direct recognition of oligodendrocytes.
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DOI：
10.1016/j.bbadis.2010.07.008
发表时间：
2011-02
影响因子：
6.2
作者：
Chastain, Emily M. L.;Duncan, D'Anne S.;Rodgers, Jane M.;Miller, Stephen D.
通讯作者：
Miller, Stephen D.
影响因子：
20.3
作者：
King, Irah L.;Dickendesher, Travis L.;Segal, Benjamin M.
通讯作者：
Segal, Benjamin M.
影响因子：
3.6
作者：
Cudrici, Cornelia;Ito, Takahiro;Rus, Horea
通讯作者：
Rus, Horea
病毒感染通过激活表达双重 TCR 的 CD8+ T 细胞触发中枢神经系统自身免疫。
影响因子：
30.5
作者：
Ji, Qingyong;Perchellet, Antoine;Goverman, Joan M.
通讯作者：
Goverman, Joan M.
DOI：
10.1084/jem.20070064
发表时间：
2007-09-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Galea I;Bernardes-Silva M;Forse PA;van Rooijen N;Liblau RS;Perry VH
通讯作者：
Perry VH