Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.
Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.
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DOI：
10.3389/fimmu.2023.1130821
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
随着新冠肺炎疫情继续影响医院系统，仍有必要更好地识别罹患2019年严重冠状病毒病（COVID-19）风险最高的患者。我们试图表征晚期糖基化终产物受体（RAGE）、SARS-CoV-2核衣壳病毒抗原和一组血栓炎症生物标志物与急诊科症状性COVID-19患者严重疾病发展的关系。77例有症状的COVID-19患者抵达时采集了血样，并测量了血浆中血栓炎症生物标志物的水平。分析出现和未出现严重疾病或在就诊后7天死亡的患者之间的生物标志物差异。经多次比较调整后，病情严重组患者RAGE、SARS-CoV-2核衣壳病毒抗原、白细胞介素(IL)-6、IL-10、肿瘤坏死因子受体(TNFR)-1水平均显著升高（p<0.05）。在多变量回归模型中，RAGE和SARS-CoV-2核衣壳病毒抗原仍然是严重疾病发展的重要危险因素（p均<0.05），切点分析的敏感性和特异性均为bb80 %。急诊就诊时RAGE和SARS-CoV-2核衣壳病毒抗原升高与7天重症发展密切相关。随着医院系统继续不堪重负，这些发现对患者预后和分诊具有临床意义。进一步的研究是有必要的，以确定可行性和实用性的点护理测量这些生物标志物在急诊科设置，以改善患者的预后和分诊。
There remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue to impact hospital systems. We sought to characterize the association of receptor for advanced glycation end products (RAGE), SARS-CoV-2 nucleocapsid viral antigen, and a panel of thromboinflammatory biomarkers with development of severe disease in patients presenting to the emergency department with symptomatic COVID-19. Blood samples were collected on arrival from 77 patients with symptomatic COVID-19, and plasma levels of thromboinflammatory biomarkers were measured. Differences in biomarkers between those who did and did not develop severe disease or death 7 days after presentation were analyzed. After adjustment for multiple comparisons, RAGE, SARS-CoV-2 nucleocapsid viral antigen, interleukin (IL)-6, IL-10 and tumor necrosis factor receptor (TNFR)-1 were significantly elevated in the group who developed severe disease (all p<0.05). In a multivariable regression model, RAGE and SARS-CoV-2 nucleocapsid viral antigen remained significant risk factors for development of severe disease (both p<0.05), and each had sensitivity and specificity >80% on cut-point analysis. Elevated RAGE and SARS-CoV-2 nucleocapsid viral antigen on emergency department presentation are strongly associated with development of severe disease at 7 days. These findings are of clinical relevance for patient prognostication and triage as hospital systems continue to be overwhelmed. Further studies are warranted to determine the feasibility and utility of point-of care measurements of these biomarkers in the emergency department setting to improve patient prognostication and triage.
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影响因子：
6.1
作者：
Chiappalupi S;Salvadori L;Vukasinovic A;Donato R;Sorci G;Riuzzi F
通讯作者：
Riuzzi F
DOI：
10.3390/diagnostics12010176
发表时间：
2022-01-12
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Ceci FM;Fiore M;Gavaruzzi F;Angeloni A;Lucarelli M;Scagnolari C;Bonci E;Gabanella F;Di Certo MG;Barbato C;Petrella C;Greco A;Vincentiis M;Ralli M;Passananti C;Poscia R;Minni A;Ceccanti M;Tarani L;Ferraguti G
通讯作者：
Ferraguti G
影响因子：
38.9
作者：
Jabaudon M;Blondonnet R;Pereira B;Cartin-Ceba R;Lichtenstern C;Mauri T;Determann RM;Drabek T;Hubmayr RD;Gajic O;Uhle F;Coppadoro A;Pesenti A;Schultz MJ;Ranieri MV;Brodska H;Mrozek S;Sapin V;Matthay MA;Constantin JM;Calfee CS
通讯作者：
Calfee CS
影响因子：
8.1
作者：
Lim A;Radujkovic A;Weigand MA;Merle U
通讯作者：
Merle U
DOI：
10.1016/j.ajem.2020.12.076
发表时间：
2021-03
期刊：
The American journal of emergency medicine
影响因子：
--
作者：
Hariyanto TI;Japar KV;Kwenandar F;Damay V;Siregar JI;Lugito NPH;Tjiang MM;Kurniawan A
通讯作者：
Kurniawan A