Early Routine Biomarkers of SARS-CoV-2 Morbidity and Mortality: Outcomes from an Emergency Section.
Early Routine Biomarkers of SARS-CoV-2 Morbidity and Mortality: Outcomes from an Emergency Section.
复制标题
DOI：
10.3390/diagnostics12010176
复制
发表时间：
2022-01-12
期刊：
影响因子：
--
通讯作者：
Ferraguti G
中科院分区：
文献类型：
--
作者：
Ceci FM;Fiore M;Gavaruzzi F;Angeloni A;Lucarelli M;Scagnolari C;Bonci E;Gabanella F;Di Certo MG;Barbato C;Petrella C;Greco A;Vincentiis M;Ralli M;Passananti C;Poscia R;Minni A;Ceccanti M;Tarani L;Ferraguti G
背景COVID-19是由SARS-CoV-2（一种属于冠状病毒科的病毒）引起的严重急性呼吸道疾病。这种疾病在世界范围内迅速蔓延，并很快成为一种国际公共卫生紧急情况，导致医院急诊部门面临不可预测的压力。早期常规血液生物标志物可能是COVID-19发病率和死亡率的关键预测因素，如C反应蛋白（CRP）、IL-6、凝血酶原和D-二聚体。本研究旨在确定其他早期常规血液生物标志物，用于直接披露到急诊科的COVID-19严重程度预测。方法.我们的研究是对2020年3月至2020年4月期间在意大利罗马的Sapienza大学医院“Policlinico Umberto I”住院的156名COVID-19患者进行的，这些患者在大流行的发作初期。在这项回顾性研究中，患者根据其结局分为三组：（1）急诊组（患者进入急诊室后不久出院，因为他们没有表现出严重的症状）;（2）重症监护室（ICU）组（进入急诊室后进入ICU的患者）;（3）死亡组（有致命结果的患者，他们参加了急诊，随后进入ICU病房）。当病人被送入急诊室时，从病历中收集常规实验室检查。我们重点关注天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌红蛋白（MGB）、铁蛋白、CRP和D-二聚体。结果正如预期的那样，ANOVA数据显示与急诊组相比，ICU组和死亡组的年龄发病率增加。方差分析揭示了发病率的主要影响，所有的分析参数与紧急组和死亡组之间的海拔。此外，还观察到ICU组与急诊组之间以及死亡组与ICU组之间的LDH、铁蛋白、CRP和D-二聚体显著升高。受试者工作特征（ROC）分析证实并扩展了这些发现。结论.这项研究表明，同时存在高水平的LDH、铁蛋白以及预期的CRP和D-二聚体可被视为COVID-19严重程度和死亡的潜在预测因素。
Background. COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, a virus belonging to the Coronaviridae family. This disease has spread rapidly around the world and soon became an international public health emergency leading to an unpredicted pressure on the hospital emergency units. Early routine blood biomarkers could be key predicting factors of COVID-19 morbidity and mortality as suggested for C-reactive protein (CRP), IL-6, prothrombin and D-dimer. This study aims to identify other early routine blood biomarkers for COVID-19 severity prediction disclosed directly into the emergency section. Methods. Our research was conducted on 156 COVID-19 patients hospitalized at the Sapienza University Hospital “Policlinico Umberto I” of Rome, Italy, between March 2020 and April 2020 during the paroxysm’s initial phase of the pandemic. In this retrospective study, patients were divided into three groups according to their outcome: (1) emergency group (patients who entered the emergency room and were discharged shortly after because they did not show severe symptoms); (2) intensive care unit (ICU) group (patients who attended the ICU after admission to the emergency unit); (3) the deceased group (patients with a fatal outcome who attended the emergency and, afterward, the ICU units). Routine laboratory tests from medical records were collected when patients were admitted to the emergency unit. We focused on Aspartate transaminase (AST), Alanine transaminase (ALT), Lactate dehydrogenase (LDH), Creatine kinase (CK), Myoglobin (MGB), Ferritin, CRP, and D-dimer. Results. As expected, ANOVA data show an age morbidity increase in both ICU and deceased groups compared with the emergency group. A main effect of morbidity was revealed by ANOVA for all the analyzed parameters with an elevation between the emergency group and the deceased group. Furthermore, a significant increase in LDH, Ferritin, CRP, and D-dimer was also observed between the ICU group and the emergency group and between the deceased group and ICU group. Receiver operating characteristic (ROC) analyses confirmed and extended these findings. Conclusions. This study suggests that the contemporaneous presence of high levels of LDH, Ferritin, and as expected, CRP, and D-dimer could be considered as potential predictors of COVID-19 severity and death.
登录
查看更多内容
DOI：
10.26355/eurrev_202108_26553
发表时间：
2021-01-01
影响因子：
3.3
作者：
Barbato, C.;Certo, M. G. Di;Minni, A.
通讯作者：
Minni, A.
DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
4
作者：
Niu, Shengmei;Tian, Sijia;Zhang, Jinjun
通讯作者：
Zhang, Jinjun
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
供临床医生使用的铁蛋白。
影响因子：
7.4
作者：
Knovich, Mary Ann;Storey, Jonathan A.;Coffman, Lan G.;Torti, Suzy V.;Torti, Frank M.
通讯作者：
Torti, Frank M.