Molecular events in hepatic preneoplasia: a review.

Molecular events in hepatic preneoplasia: a review.
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DOI:
10.1016/j.yexmp.2010.01.005
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发表时间:
2010-04
影响因子:
3.6
通讯作者:
French, S. W.
French, S. W.
中科院分区:
医学3区
文献类型:
--
作者:
French, S. W.

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已经进行的人体研究表明,直径在1 mm和1 cm之间的发育异常结节是癌前病变(肝细胞肿瘤国际共识小组2009),直径小于1 mm的显微镜病灶被称为发育异常病灶。大细胞改变(以前称为大细胞发育不良)与肝细胞癌(HCC)有关,但并不代表HCC的真正前驱病变。另一方面,小细胞变化(以前称为小细胞发育不良)被认为是HCC的直接前兆(Desmet 2009)。到目前为止,发育异常病灶的分子病理学变化尚未确定。
Human studies have been done which indicate that dysplastic nodules between 1 mm and 1 cm in diameter are precancerous (International concensus Group for Hepatocellular Neoplasms 2009) Microscopic foci less than 1 mm in diameter are referred to as dysplastic foci. Large cell change (previously called large cell dysplasia) is associated with hepatocellular carcinoma (HCC) but does not represent a true precursor lesion for HCC. On the other hand small cell change (previously called small cell dysplasia) is considered a direct precursor of HCC (Desmet 2009). So far, changes in molecular pathology of dysplastic foci have not been established.
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