Sex differences in drug use among polysubstance users.
Sex differences in drug use among polysubstance users.
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DOI：
10.1016/j.drugalcdep.2014.10.003
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发表时间：
2014-12-01
影响因子：
4.2
通讯作者：
Nixon, Sara Jo
中科院分区：
文献类型：
--
作者：
Lewis, Ben;Hoffman, Lauren A.;Nixon, Sara Jo
现有证据表明，患有物质使用障碍的妇女可能会经历更快的进展，通过使用里程碑（伸缩）。对寻求治疗人群中性别差异的少数调查往往侧重于单一物质，通常不考虑大量的多种物质滥用。目前的研究探讨了寻求治疗的多物质使用者的异质样本中的性别差异。我们检查了药物使用的模式，药物使用里程碑的年龄（例如，初始使用、常规使用）和里程碑之间的进展率。尼古丁和酒精的使用也进行了评估。参与者（N=543; 288名妇女）完成了物质使用的个人历史，包括慢性，频率和规律性，以及评估影响和智力的清单。药物使用率和里程碑年龄因性别和特定药物而异。分析表明，止痛药和大麻具有明显的伸缩效应，女性在使用里程碑时进展更快。我们的数据一般支持的伸缩效应，虽然进展措施的相当大的差异。在止痛药使用中观察到的显著伸缩与其他阿片类药物中没有伸缩之间的对比特别令人感兴趣。尽管有共同的药理学，但伸缩效应的差异表明需要进一步研究潜在的心理社会因素。这些结果强调，具体的样本人群，物质和结果的措施，应仔细考虑在解释物质使用的性别差异。
Available evidence indicates women with substance use disorders may experience more rapid progression through usage milestones (telescoping). The few investigations of sex differences in treatment-seeking populations often focus on single substances and typically do not account for significant polysubstance abuse. The current study examined sex differences in a heterogeneous sample of treatment seeking polysubstance users. We examined patterns of drug use, age at drug use milestones (e.g., initial use, regular use), and progression rates between milestones. Nicotine and alcohol use were also evaluated. Participants (N=543; 288 women) completed personal histories of substance use, including chronicity, frequency, and regularity, as well as inventories assessing affect, and intellectual ability. Rates of drug use and milestone ages varied by sex and specific drug. Analyses suggested pronounced telescoping effects for pain medication and marijuana, with women progressing more rapidly through usage milestones. Our data were generally supportive of telescoping effects, although considerable variance in progression measures was noted. The contrast between the marked telescoping observed in pain medication use and the absence of telescoping in other opioids was of particular interest. The discrepancy in telescoping effects, despite shared pharmacologies, suggests the need for further work examining underlying psychosocial factors. These results highlight that the specific sample population, substance, and outcome measure should be carefully considered when interpreting sex differences in substance use.
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影响因子：
4.4
作者：
McCabe, SE;Boyd, CJ
通讯作者：
Boyd, CJ
影响因子：
4.2
作者：
Hernandez-Avila, CA;Rounsaville, BJ;Kranzler, HR
通讯作者：
Kranzler, HR
DOI：
10.1016/s0899-3289(00)00053-5
发表时间：
2000-01-01
期刊：
JOURNAL OF SUBSTANCE ABUSE
影响因子：
--
作者：
Haas, AL;Peters, RH
通讯作者：
Peters, RH
影响因子：
1.7
作者：
Greenfield, Shelly F.;Back, Sudie E.;Lawson, Katie;Brady, Kathleen T.
通讯作者：
Brady, Kathleen T.
影响因子：
4.2
作者：
Green, Traci C.;Serrano, Jill M. Grimes;Licari, Andrea;Budman, Simon H.;Butler, Stephen F.
通讯作者：
Butler, Stephen F.