fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation.
fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation.
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DOI：
10.3389/fpsyt.2021.715898
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发表时间：
2021
影响因子：
4.7
通讯作者：
Mathiak K
中科院分区：
文献类型：
--
作者：
Keller M;Zweerings J;Klasen M;Zvyagintsev M;Iglesias J;Mendoza Quiñones R;Mathiak K
情感障碍与不适应的情绪调节策略有关。特别是，左侧多于右侧腹外侧额叶皮质(VLPFC)可能不足以调节情绪处理，例如，在杏仁核。一项双盲交叉研究调查了在重度抑郁症(n=42)和年龄和性别匹配的对照组(n=39)中接受核因子支持的认知重新评估训练。参与者按随机顺序接受训练，在两个不同的日子对负面图像进行认知重新评估时，上调左侧或右侧的VLPFC。我们想要证实与右侧VLPFC(ClinicalTrials.gov NCT03183947)相比，左侧学习能力改善的区域特异性神经营养因子效应。在为期4周的随访中，研究了训练进度、性别和临床结果方面的大脑反应和连通性。神经营养因子训练后，左侧大脑半球VLPFC活性的增加幅度大于右侧。在认知再评估过程中，这种区域性的神经营养因子效应在抑郁症患者和对照组中都存在，并支持左侧VLPFC在认知重新评估中的核心作用。此外，左侧靶区的活动与认知重新评估策略的使用增加相关(r=0.48)。在为期4周的随访中，75%的抑郁症患者报告在日常生活中成功地应用了所学的策略，55%的患者报告了临床上有意义的症状改善，表明了临床上的可用性。
Affective disorders are associated with maladaptive emotion regulation strategies. In particular, the left more than the right ventrolateral prefrontal cortex (vlPFC) may insufficiently regulate emotion processing, e.g., in the amygdala. A double-blind cross-over study investigated NF-supported cognitive reappraisal training in major depression (n = 42) and age- and gender-matched controls (n = 39). In a randomized order, participants trained to upregulate either the left or the right vlPFC during cognitive reappraisal of negative images on two separate days. We wanted to confirm regional specific NF effects with improved learning for left compared to right vlPFC (ClinicalTrials.gov NCT03183947). Brain responses and connectivity were studied with respect to training progress, gender, and clinical outcomes in a 4-week follow-up. Increase of vlPFC activity was stronger after NF training from the left- than the right-hemispheric ROI. This regional-specific NF effect during cognitive reappraisal was present across patients with depression and controls and supports a central role of the left vlPFC for cognitive reappraisal. Further, the activity in the left target region was associated with increased use of cognitive reappraisal strategies (r = 0.48). In the 4-week follow-up, 75% of patients with depression reported a successful application of learned strategies in everyday life and 55% a clinically meaningful symptom improvement suggesting clinical usability.
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影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.
影响因子：
4.2
作者：
Denny, Bryan T.
通讯作者：
Denny, Bryan T.
影响因子：
3.1
作者：
Drevets, Wayne C.;Price, Joseph L.;Furey, Maura L.
通讯作者：
Furey, Maura L.
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.