Whole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection.
Whole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection.
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DOI：
10.3390/antibiotics11020218
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发表时间：
2022-02-09
期刊：
影响因子：
--
通讯作者：
Zwickey H
中科院分区：
文献类型：
--
作者：
Garofalo L;Nakama C;Hanes D;Zwickey H
A healthy urinary tract contains a variety of microbes resulting in a diverse urobiome. Urobiome dysbiosis, defined as an imbalance in the microbial composition in the microenvironments along the urinary tract, is found in women with uncomplicated urinary tract infection (UTI). Historically, antibiotics have been used to address UTI. An alternative approach to uncomplicated UTI is warranted as the current paradigm fails to take urobiome dysbiosis into account and contributes to the communal problem of resistance. A whole-person, multi-modal approach that addresses vaginal and urinary tract dysbiosis may be more effective in reducing recurrent UTI. In this review, we discuss strategies that include reducing pathogenic bacteria while supporting commensal urogenital bacteria, encouraging diuresis, maintaining optimal pH levels, and reducing inflammation. Strategies for future research are suggested.
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影响因子：
2.9
作者：
Chen, Liang;Hu, Chun;Du, Jun
通讯作者：
Du, Jun
DOI：
10.3390/antibiotics10040373
发表时间：
2021-04-01
期刊：
Antibiotics (Basel, Switzerland)
影响因子：
--
作者：
De Nunzio C;Bartoletti R;Tubaro A;Simonato A;Ficarra V
通讯作者：
Ficarra V
DOI：
10.3390/molecules25235593
发表时间：
2020-11-28
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Chandra H;Singh C;Kumari P;Yadav S;Mishra AP;Laishevtcev A;Brisc C;Brisc MC;Munteanu MA;Bungau S
通讯作者：
Bungau S
影响因子：
5.2
作者：
Deshpande, Abhishek;Pasupuleti, Vinay;Donskey, Curtis J.
通讯作者：
Donskey, Curtis J.
DOI：
10.1136/bmj.i939
发表时间：
2016-03-15
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Bryce A;Hay AD;Lane IF;Thornton HV;Wootton M;Costelloe C
通讯作者：
Costelloe C