CMOS Microflow Cytometer for Magnetic Label Detection and Classification

CMOS Microflow Cytometer for Magnetic Label Detection and Classification
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用于磁性标签检测和分类的 CMOS 微流式细胞仪

DOI:
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发表时间:
2014
影响因子:
5.4
通讯作者:
B. Boser
B. Boser
中科院分区:
工程技术1区
文献类型:
--
作者:
P. Murali;A. Niknejad;B. Boser

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提出了一种采用 65 nm 标准 CMOS 技术制造并嵌入微流体通道的流式细胞仪芯片。该芯片通过解调差分螺旋变压器的励磁线圈和拾波线圈之间的耦合变化来检测带有磁性标签的细胞。使用 EpCAM-生物素-链霉亲和素化学方法验证了流式细胞仪盒的操作,可检测带有锰铁氧体磁性标记的 SKBR-3 乳腺癌细胞。不同材料的磁性标签根据其复磁化率相位的差异进行分类。
A flow cytometer chip fabricated in 65-nm standard CMOS technology embedded into a microfluidic channel is presented. The chip detects cells specifically tagged with magnetic labels by demodulating the change in coupling between an excitation coil and a pickup coil of a differential spiral transformer. Operation of the flow cytometer cartridge is verified for the detection of SKBR-3 breast cancer cells tagged with manganese ferrite magnetic labels using EpCAM-biotin-streptavidin chemistry. Magnetic labels of different materials are classified by the difference in the phase of their complex susceptibility.
DOI: 10.1039/b912214a
发表时间: 2009-11-21
期刊: Lab on a chip
影响因子: 6.1
作者:
Watkins N;Venkatesan BM;Toner M;Rodriguez W;Bashir R
通讯作者: Bashir R
DOI: 10.1039/c2lc40759k
发表时间: 2012-11-07
期刊: Lab on a chip
影响因子: 6.1
作者:
Emaminejad S;Javanmard M;Dutton RW;Davis RW
通讯作者: Davis RW