Distinct face-processing strategies in parents of autistic children.
Distinct face-processing strategies in parents of autistic children.
复制标题
DOI：
10.1016/j.cub.2008.06.073
复制
发表时间：
2008-07-22
期刊：
影响因子：
9.2
通讯作者：
Piven, Joseph
中科院分区：
文献类型：
--
作者：
Adolphs, Ralph;Spezio, Michael L.;Parlier, Morgan;Piven, Joseph
在他最初对自闭症的描述中，坎纳指出，自闭症儿童的父母自己经常表现出不寻常的社交行为，这与我们现在所知的自闭症的高遗传率是一致的。我们在自闭症儿童的父母中调查了这种所谓的“广泛的自闭症表型”，这些自闭症儿童本身没有任何精神疾病的诊断。在最近对自闭症的社会认知进行量化的基础上，我们使用“气泡”方法研究了面部加工，以衡量观众如何利用来自特定面部特征的信息来判断情绪。自闭症儿童的父母被评估为社交冷漠(N=15)，这是表型的关键组成部分，与神经典型儿童的父母(N=20)和非冷漠的自闭症儿童的父母(N=27，其面孔加工模式为中等)相比，他们在处理面部眼睛区域的过程中显著减少，并增强了嘴巴的处理能力。在广泛的自闭症表型中看到的面部处理模式与之前报道的自闭症患者的面孔处理模式惊人地相似，这第一次提供了一扇窗，揭示了可能由有助于社会认知的基因子集导致的内在表型。
In his original description of autism, Kanner noted that the parents of autistic children often exhibited unusual social behavior themselves, consistent with what we now know about the high heritability of autism. We investigated this so-called “Broad Autism Phenotype” in the parents of children with autism, who themselves did not have a diagnosis of any psychiatric illness. Building on recent quantifications of social cognition in autism, we investigated face processing using the “Bubbles” method to measure how viewers make use of information from specific facial features in order to judge emotions. Parents of autistic children who were assessed as socially aloof (N=15), a key component of the phenotype, showed a remarkable reduction in processing the eye region in faces, together with enhanced processing of the mouth, compared to a control group of parents of neurotypical children (N=20), as well as to non-aloof parents of autistic children (N=27, whose pattern of face processing was intermediate). The pattern of face processing seen in the Broad Autism Phenotype showed striking similarities to that previously reported to occur in autism, and for the first time provides a window into the endophenotype that may result from a subset of the genes that contribute to social cognition.
登录
查看更多内容
影响因子：
1.8
作者：
Gosselin, F;Schyns, PG
通讯作者：
Schyns, PG
影响因子：
3.9
作者：
Merin, Noah;Young, Gregory S.;Rogers, Sally J.
通讯作者：
Rogers, Sally J.
影响因子：
--
作者：
Nacewicz, Brendon M.;Dalton, Kim M.;Davidson, Richard J.
通讯作者：
Davidson, Richard J.
影响因子：
--
作者：
Klin, A;Jones, W;Cohen, D
通讯作者：
Cohen, D
影响因子：
64.8
作者：
Adolphs, R;Gosselin, F;Damasio, AR
通讯作者：
Damasio, AR