Persistent pneumocystis colonization leads to the development of chronic obstructive pulmonary disease in a nonhuman primate model of AIDS.
Persistent pneumocystis colonization leads to the development of chronic obstructive pulmonary disease in a nonhuman primate model of AIDS.
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DOI：
10.1086/653485
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发表时间：
2010-07-15
期刊：
影响因子：
--
通讯作者：
Norris KA
中科院分区：
文献类型：
--
作者：
Shipley TW;Kling HM;Morris A;Patil S;Kristoff J;Guyach SE;Murphy JE;Shao X;Sciurba FC;Rogers RM;Richards T;Thompson P;Montelaro RC;Coxson HO;Hogg JC;Norris KA
HIV-infected patients are at increased risk for development of pulmonary complications, including chronic obstructive pulmonary disease (COPD). Inflammation associated with sub-clinical infection has been postulated to promote COPD. Persistence of Pneumocystis (Pc) is associated with HIV and COPD, although a causal relationship has not been established. We used a simian/human immunodeficiency virus (SHIV) model of HIV infection to study pulmonary effects of Pc colonization. SHIV-infected/Pc-colonized monkeys developed progressive obstructive pulmonary disease characterized by increased emphysematous tissue and bronchial-associated lymphoid tissue. Elevated Th2 cytokines and pro-inflammatory mediators in bronchoalveolar lavage fluid coincided with Pc colonization and pulmonary function decline. These results support the concept that an infectious agent contributes to development of HIV-associated lung disease and suggests that Pc colonization may be a risk factor for the development of HIV-associated COPD. Furthermore, this model allows examination of early host responses important to disease progression thus identifying potential therapeutic targets for COPD.
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影响因子：
6.2
作者：
Gigliotti, Francis;Wright, Terry W.
通讯作者：
Wright, Terry W.
DOI：
10.1164/ajrccm.159.3.9805067
发表时间：
1999-03-01
影响因子：
24.7
作者：
Coxson, HO;Rogers, RM;Hogg, JC
通讯作者：
Hogg, JC
DOI：
10.1164/ajrccm.159.6.9809043
发表时间：
1999-06-01
影响因子：
24.7
作者：
Betsuyaku, T;Nishimura, M;Kawakami, Y
通讯作者：
Kawakami, Y
影响因子：
1.5
作者：
Joag, SV;Li, ZA;Narayan, O
通讯作者：
Narayan, O
影响因子：
9.6
作者：
Crothers, Kristina;Butt, Adeel A.;Justice, Amy C.
通讯作者：
Justice, Amy C.