Towards an understanding of the adjuvant action of aluminium.

Towards an understanding of the adjuvant action of aluminium.
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DOI:
10.1038/nri2510
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发表时间:
2009-04
期刊:
Nature reviews. Immunology
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疫苗的效力取决于与抗原结合的佐剂的存在。在这些佐剂中,1926年首次凭经验发现的含铝佐剂目前使用最广泛。然而,对其作用机制的详细了解才刚刚开始。在这篇时间轴文章中,我们简要描述了铝佐剂的最初发现,并讨论了历史上的重要进展。我们还总结了该领域的最新进展,并讨论了它们的影响和这些佐剂如何工作的剩余问题。
The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.
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