Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes.
Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes.
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DOI：
10.1007/s40471-018-0140-5
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发表时间：
2018-06
影响因子：
3.3
通讯作者：
Gilliland FD
中科院分区：
文献类型：
--
作者：
Alderete TL;Chen Z;Toledo-Corral CM;Contreras ZA;Kim JS;Habre R;Chatzi L;Bastain T;Breton CV;Gilliland FD
糖尿病是造成全球成人死亡和残疾负担的最大因素。在年轻人中，糖尿病前期和2型糖尿病的发病率也出现了缓慢但稳定的上升。目前的综述总结了有关空气污染物暴露增加对2型糖尿病流行的影响的最新研究结果。人类和动物研究提供了强有力的证据，表明暴露在环境和交通相关空气污染物中，如颗粒物(PM)、二氧化氮(NO2)和氮氧化物(NOx)在代谢功能障碍和2型糖尿病病因中发挥着重要作用。这项工作得到了最近发现的支持，这些发现观察到增加暴露在空气污染物中对儿童和成人2型糖尿病风险的临床测量的影响大小相似。此外，研究表明，在存在肥胖和糖尿病前期等危险因素的个体中，这些影响可能更加明显。目前的流行病学证据表明，暴露于空气污染的增加会导致胰岛素信号、葡萄糖代谢和β细胞功能的改变。未来的工作需要确定改变葡萄糖代谢的特定有害污染物。此外，先进的工具和新的研究领域为研究将空气污染暴露增加与2型糖尿病发病联系起来的潜在机制提供了独特的机会，包括中间途径。
Diabetes mellitus is a top contributor to the global burden of mortality and disability in adults. There has also been a slow, but steady rise in prediabetes and type 2 diabetes in youth. The current review summarizes recent findings regarding the impact of increased exposure to air pollutants on the type 2 diabetes epidemic. Human and animal studies provide strong evidence that exposure to ambient and traffic-related air pollutants such as particulate matter (PM), nitrogen dioxide (NO2), and nitrogen oxides (NOx) play an important role in metabolic dysfunction and type 2 diabetes etiology. This work is supported by recent findings that have observed similar effect sizes for increased exposure to air pollutants on clinical measures of risk for type 2 diabetes in children and adults. Further, studies indicate that these effects may be more pronounced among individuals with existing risk factors, including obesity and prediabetes. Current epidemiological evidence suggests that increased air pollution exposure contributes to alterations in insulin signaling, glucose metabolism, and beta (β)-cell function. Future work is needed to identify the specific detrimental pollutants that alter glucose metabolism. Additionally, advanced tools and new areas of investigation present unique opportunities to study the underlying mechanisms, including intermediate pathways, that link increased air pollution exposure with type 2 diabetes onset.
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DOI：
10.1161/hypertensionaha.115.06237
发表时间：
2016-01
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Brook RD;Sun Z;Brook JR;Zhao X;Ruan Y;Yan J;Mukherjee B;Rao X;Duan F;Sun L;Liang R;Lian H;Zhang S;Fang Q;Gu D;Sun Q;Fan Z;Rajagopalan S
通讯作者：
Rajagopalan S
影响因子：
7.7
作者：
Floegel A;Stefan N;Yu Z;Mühlenbruch K;Drogan D;Joost HG;Fritsche A;Häring HU;Hrabě de Angelis M;Peters A;Roden M;Prehn C;Wang-Sattler R;Illig T;Schulze MB;Adamski J;Boeing H;Pischon T
通讯作者：
Pischon T
影响因子：
3.7
作者：
Eze IC;Schaffner E;Foraster M;Imboden M;von Eckardstein A;Gerbase MW;Rothe T;Rochat T;Künzli N;Schindler C;Probst-Hensch N
通讯作者：
Probst-Hensch N
影响因子：
7.7
作者：
Alderete, Tanya L.;Habre, Rima;Gilliland, Frank D.
通讯作者：
Gilliland, Frank D.
影响因子：
16.2
作者：
Eppens, Maike C.;Craig, Maria E.;Donaghue, Kim C.
通讯作者：
Donaghue, Kim C.