Long-Term Exposure to Ambient Air Pollution and Metabolic Syndrome in Adults.
Long-Term Exposure to Ambient Air Pollution and Metabolic Syndrome in Adults.
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DOI：
10.1371/journal.pone.0130337
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Probst-Hensch N
中科院分区：
文献类型：
--
作者：
Eze IC;Schaffner E;Foraster M;Imboden M;von Eckardstein A;Gerbase MW;Rothe T;Rochat T;Künzli N;Schindler C;Probst-Hensch N
空气污染物（AP）在亚临床炎症中发挥作用，并与心血管发病率和死亡率相关。代谢综合征（MetS）是炎症性的，并且先于心血管发病率和2型糖尿病。因此，可以假设AP和MetS之间存在正相关。我们探讨了这种关联，（考虑到，特定的代谢途径的定义），其潜在的修饰符在瑞士成年人。我们研究了3769名参与瑞士队列研究的成年人空气污染与肺和心脏疾病，报告静脉穿刺前至少禁食4小时。AP暴露是10年平均居住PM10（直径<10μm的颗粒物）和NO2（二氧化氮）。结果包括世界卫生组织（MetS-W）、国际糖尿病联合会（MetS-I）和成人治疗小组III（MetS-A）使用4小时和8小时禁食时间限制定义的MetS。我们还探讨了与代谢综合征的各个组成部分的关联。我们应用混合逻辑回归模型来探索这些关联。MetS-W、MetS-I和MetS-A的检出率分别为10%、22%和18%。10年平均PM10每增加10μg/m3，MetS-W、MetS-I和MetS-A的几率分别增加72%（51-102%）、31%（11-54%）和18%（4-34%）。我们观察到与NO2的关联较弱。在体力活动、吸烟者和非糖尿病参与者中，尤其是与PM10的相关性更强（p<0.05）。在各种敏感性分析中，相关性仍然很强，包括对缺失观察结果的10次插补和排除糖尿病病例。所观察到的AP暴露和代谢综合征之间的关联是敏感的代谢综合征的定义。关于代谢综合征的组成部分，我们观察到与空腹血糖受损的最强关联，与高血压和腰围肥胖的正相关但较弱。AP的非代谢效应可能主要由葡萄糖稳态的损害驱动，并且在不太强烈的程度上，内脏肥胖。需要精心设计的前瞻性研究来证实这些发现。
Air pollutants (AP) play a role in subclinical inflammation, and are associated with cardiovascular morbidity and mortality. Metabolic syndrome (MetS) is inflammatory and precedes cardiovascular morbidity and type 2 diabetes. Thus, a positive association between AP and MetS may be hypothesized. We explored this association, (taking into account, pathway-specific MetS definitions), and its potential modifiers in Swiss adults. We studied 3769 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults, reporting at least four-hour fasting time before venepuncture. AP exposures were 10-year mean residential PM10 (particulate matter <10μm in diameter) and NO2 (nitrogen dioxide). Outcomes included MetS defined by World Health Organization (MetS-W), International Diabetes Federation (MetS-I) and Adult Treatment Panel-III (MetS-A) using four- and eight-hour fasting time limits. We also explored associations with individual components of MetS. We applied mixed logistic regression models to explore these associations. The prevalence of MetS-W, MetS-I and MetS-A were 10%, 22% and 18% respectively. Odds of MetS-W, MetS-I and MetS-A increased by 72% (51-102%), 31% (11-54%) and 18% (4-34%) per 10μg/m3 increase in 10-year mean PM10. We observed weaker associations with NO2. Associations were stronger among physically-active, ever-smokers and non-diabetic participants especially with PM10 (p<0.05). Associations remained robust across various sensitivity analyses including ten imputations of missing observations and exclusion of diabetes cases. The observed associations between AP exposure and MetS were sensitive to MetS definitions. Regarding the MetS components, we observed strongest associations with impaired fasting glycemia, and positive but weaker associations with hypertension and waist-circumference-based obesity. Cardio-metabolic effects of AP may be majorly driven by impairment of glucose homeostasis, and to a less-strong extent, visceral adiposity. Well-designed prospective studies are needed to confirm these findings.
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影响因子：
10
作者：
Miller MR;McLean SG;Duffin R;Lawal AO;Araujo JA;Shaw CA;Mills NL;Donaldson K;Newby DE;Hadoke PW
通讯作者：
Hadoke PW
影响因子：
10
作者：
Krishnan RM;Sullivan JH;Carlsten C;Wilkerson HW;Beyer RP;Bammler T;Farin F;Peretz A;Kaufman JD
通讯作者：
Kaufman JD
DOI：
10.1080/15287394.2014.892446
发表时间：
2014
期刊：
Journal of toxicology and environmental health. Part A
影响因子：
--
作者：
Brocato J;Sun H;Shamy M;Kluz T;Alghamdi MA;Khoder MI;Chen LC;Costa M
通讯作者：
Costa M
DOI：
10.1007/s00038-005-4075-5
发表时间：
2005-01-01
期刊：
SOZIAL-UND PRAVENTIVMEDIZIN
影响因子：
--
作者：
Ackermann-Liebrich, U;Kuna-Dibbert, B;Leuenberger, P
通讯作者：
Leuenberger, P
影响因子：
16.2
作者：
Andersen ZJ;Raaschou-Nielsen O;Ketzel M;Jensen SS;Hvidberg M;Loft S;Tjønneland A;Overvad K;Sørensen M
通讯作者：
Sørensen M