Incidence and outcomes of lymphoid malignancies in adolescent and young adult patients in the United States.
Incidence and outcomes of lymphoid malignancies in adolescent and young adult patients in the United States.
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DOI：
10.1111/bjh.15532
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发表时间：
2018-11
影响因子：
6.5
通讯作者：
Flowers CR
中科院分区：
文献类型：
--
作者：
Blum KA;Keller FG;Castellino S;Phan A;Flowers CR
使用监测、流行病学和最终结果（SEER）数据评估了青少年和年轻人（AYA，定义为15至39岁）以及成人患者（> 39岁）的淋巴瘤发病率和生存率。从2000年到2014年，SEER报告了431，721例淋巴瘤病例，其中9%为AYA患者。在AYA组中，年龄校正后的发病率最高的是经典型霍奇金淋巴瘤（HL; 3.4/100，000人-年; 95%置信区间[CI]，3.38-3.49），其次为弥漫性大B细胞淋巴瘤（DLBCL; 1.56，95%CI，1.53 -1.60），成人为浆细胞肿瘤（14.17，95% CI，14.07-14.27）、DLBCL（13.86，95% CI，13.76-13.96）和慢性淋巴细胞白血病（CLL; 13.19，95% CI，13.09-13.29）。HL占AYA淋巴瘤病例的42%，但成人仅占4%。DLBCL在AYA和成人中的发生率相似，分别为18%和20%。与9%的成年人相比，28%的AYA患有II期疾病，21%的AYA患有B症状，而10%的成年人患有B症状。结外疾病在AYA中的发生率（33%）低于成人（59%）。总体而言，淋巴瘤AYA患者的2年和5年相对生存率（RSRs）优于成人。当仅限于HL和DLBCL时，AYA患者的RSR超过成人RSR。
Lymphoma incidence and survival in adolescent and young adult (AYA, defined as 15 to 39 years of age) and adult patients (> 39 years) were assessed using Surveillance, Epidemiology, and End Results (SEER) data. From 2000 to 2014, 431,721 lymphoma cases were reported to SEER, 9% in AYA patients. In the AYA group, the highest age-adjusted incidence rate was for classical Hodgkin lymphoma (HL; 3.4 per 100,000 person-years; 95% confidence interval [CI], 3.38–3.49) followed by diffuse large B cell lymphoma (DLBCL; 1.56, 95% CI,1.53–1.60) and for adults, it was plasma cell neoplasms (14.17, 95% CI, 14.07–14.27), DLBCL (13.86, 95% CI, 13.76–13.96) and chronic lymphocytic leukaemia (CLL; 13.19, 95% CI, 13.09–13.29). HL comprised 42% of lymphoma cases for AYAs, but only 4% in adults. The occurrence of DLBCL among AYAs and adults was similar, 18% and 20%, respectively. Twenty-eight percent of AYAs compared with 9% of adults presented with stage II disease, and 21% of AYAs compared with 10% of adults had B-symptoms. Extranodal disease was less common (33%) in AYAs than adults (59%). Overall, AYA patients with lymphoma have better 2- and 5-year relative survival rates (RSRs) to adults. When restricted to HL and DLBCL, RSR of AYA patients exceeds adult RSR.
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影响因子：
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作者：
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