Oxytocin-a social peptide? Deconstructing the evidence.
Oxytocin-a social peptide? Deconstructing the evidence.
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DOI：
10.1098/rstb.2021.0055
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发表时间：
2022-08-29
影响因子：
6.3
通讯作者：
Ludwig, Mike
中科院分区：
文献类型：
--
作者：
Leng, Gareth;Leng, Rhodri, I;Ludwig, Mike
在本文中，我们分析了催产素是一种“社会神经肽”的说法。这一主张源于有证据表明催产素有助于启动母性行为，并扩展到催产素在促进个体之间的社会互动中发挥关键作用的主张。我们首先考虑有关该主题的科学文献的结构，确定有关特定主题的紧密关联的论文簇。然后，我们通过考虑这些簇产生的四种类型的证据来分析这一主张：（i）动物模型中的机制研究，旨在了解集中施用催产素的行为影响所涉及的途径； (ii) 观察研究的证据表明催产素信号通路与社会行为之间存在关联； (iii) 干预研究的证据，主要涉及鼻内施用催产素； (iv) 来自社会行为障碍患者转化研究的证据。然后，我们批判性地分析每个证据部分中被引用次数最多的论文；我们的结论是，如果这些是最好的证据，那么该主张的证据就很薄弱。本文是主题“催产素和其他神经调节剂在塑造复杂社会行为中的相互作用”的一部分。
In this paper, we analyse the claim that oxytocin is a ‘social neuropeptide’. This claim originated from evidence that oxytocin was instrumental in the initiation of maternal behaviour and it was extended to become the claim that oxytocin has a key role in promoting social interactions between individuals. We begin by considering the structure of the scientific literature on this topic, identifying closely interconnected clusters of papers on particular themes. We then analyse this claim by considering evidence of four types as generated by these clusters: (i) mechanistic studies in animal models, designed to understand the pathways involved in the behavioural effects of centrally administered oxytocin; (ii) evidence from observational studies indicating an association between oxytocin signalling pathways and social behaviour; (iii) evidence from intervention studies, mainly involving intranasal oxytocin administration; and (iv) evidence from translational studies of patients with disorders of social behaviour. We then critically analyse the most highly cited papers in each segment of the evidence; we conclude that, if these represent the best evidence, then the evidence for the claim is weak. This article is part of the theme issue ‘Interplays between oxytocin and other neuromodulators in shaping complex social behaviours’.
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