Endogenous tick viruses and modulation of tick-borne pathogen growth.
Endogenous tick viruses and modulation of tick-borne pathogen growth.
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DOI：
10.3389/fcimb.2013.00025
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发表时间：
2013
影响因子：
5.7
通讯作者：
Attoui H
中科院分区：
文献类型：
--
作者：
Bell-Sakyi L;Attoui H
蜱传播各种病毒、细菌和原生动物病原体，其中许多病原体可在媒介蜱中建立终身持续感染，在某些情况下经卵传播给下一代。此外，许多硬蜱和硬蜱细胞系，以及由此推断它们所来源的亲本蜱，携带几乎一无所知的内源性病毒（ETV）。一般来说，病毒病原体（虫媒病毒）的低水平持续感染对蜱虫的存活和健康没有有害影响，这表明它们可以与蜱虫先天免疫反应取得平衡。这种虫媒病毒感染的耐受性可以通过宿主细胞中ETV的永久存在来调节。在蚊子细胞中，通过RNA干扰暂时或永久沉默内源性病毒的基因可导致共感染虫媒病毒复制速率的变化。我们建议，蜱细胞系提供了一个有用的模型系统，在体外调查ETV的调制作用的重叠感染病原体的生存和复制蜱，使用分子操作技术应用于昆虫细胞。
Ticks transmit a wide range of viral, bacterial and protozoan pathogens, many of which can establish persistent infections of lifelong duration in the vector tick and in some cases are transmitted transovarially to the next generation. In addition many ixodid and argasid tick cell lines and, by inference the parent ticks from which they were derived, harbor endogenous viruses (ETV) of which almost nothing is known. In general, low level persistent infections with viral pathogens (arboviruses) are not known to have a deleterious effect on tick survival and fitness, suggesting that they can strike a balance with the tick innate immune response. This tolerance of arbovirus infection may be modulated by the permanent presence of ETV in the host cell. In mosquito cells, temporary or permanent silencing of the genes of an endogenous virus by RNA interference can result in changes in replication rate of a co-infecting arbovirus. We propose that tick cell lines offer a useful model system for in vitro investigation of the modulatory effect of ETV on superinfecting pathogen survival and replication in ticks, using the molecular manipulation techniques applied to insect cells.
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影响因子：
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