The Basic Immune Simulator: an agent-based model to study the interactions between innate and adaptive immunity.
The Basic Immune Simulator: an agent-based model to study the interactions between innate and adaptive immunity.
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DOI：
10.1186/1742-4682-4-39
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发表时间：
2007-09-27
影响因子：
--
通讯作者：
Orosz, Charles G.
中科院分区：
文献类型：
--
作者：
Folcik, Virginia A.;An, Gary C.;Orosz, Charles G.
我们介绍了基本免疫模拟器(BIS)，这是一个基于代理的模型，用于研究先天免疫系统和获得性免疫系统细胞之间的相互作用。先天免疫是宿主对病原体的初始反应，通常先于获得性免疫，后者为抗原产生免疫记忆。BIS模拟基本细胞类型、介体和抗体，由代表实质组织、次级淋巴组织和淋巴/体液循环的三个虚拟空间组成。国际清算银行包括一个图形用户界面(图形用户界面)，以促进其作为教育和研究工具的使用。BIS被用来定性地检查对病毒感染的免疫反应的先天和适应性相互作用。校准是通过扫描初始试剂种群大小的参数，并将模拟模式与基础科学文献中报告的模式进行比较来完成的。国际清算银行证明，初始先天反应的程度是适当的适应性反应的关键决定因素。先天免疫不足或过多都会导致获得性免疫细胞过度增殖。任何免疫系统成分的缺陷都增加了未能清除模拟病毒感染的可能性。BIS的行为与一般病毒感染场景中的正常和病理行为模式相匹配。因此，BIS有效地翻译了关于先天性和获得性免疫反应的机械性细胞和分子知识，并再现了免疫系统的复杂行为模式。国际清算银行既可以作为一种教育工具来展示这些模式的出现，也可以作为一种研究工具来系统地确定潜在的目标，以便为包括过敏反应(过敏、哮喘)、自身免疫和癌症在内的疾病过程制定更有效的治疗策略。我们相信，国际清算银行可以是一个有用的补充，作为传统研究工作的辅助工具，越来越多的硅内平台。
We introduce the Basic Immune Simulator (BIS), an agent-based model created to study the interactions between the cells of the innate and adaptive immune system. Innate immunity, the initial host response to a pathogen, generally precedes adaptive immunity, which generates immune memory for an antigen. The BIS simulates basic cell types, mediators and antibodies, and consists of three virtual spaces representing parenchymal tissue, secondary lymphoid tissue and the lymphatic/humoral circulation. The BIS includes a Graphical User Interface (GUI) to facilitate its use as an educational and research tool. The BIS was used to qualitatively examine the innate and adaptive interactions of the immune response to a viral infection. Calibration was accomplished via a parameter sweep of initial agent population size, and comparison of simulation patterns to those reported in the basic science literature. The BIS demonstrated that the degree of the initial innate response was a crucial determinant for an appropriate adaptive response. Deficiency or excess in innate immunity resulted in excessive proliferation of adaptive immune cells. Deficiency in any of the immune system components increased the probability of failure to clear the simulated viral infection. The behavior of the BIS matches both normal and pathological behavior patterns in a generic viral infection scenario. Thus, the BIS effectively translates mechanistic cellular and molecular knowledge regarding the innate and adaptive immune response and reproduces the immune system's complex behavioral patterns. The BIS can be used both as an educational tool to demonstrate the emergence of these patterns and as a research tool to systematically identify potential targets for more effective treatment strategies for diseases processes including hypersensitivity reactions (allergies, asthma), autoimmunity and cancer. We believe that the BIS can be a useful addition to the growing suite of in-silico platforms used as an adjunct to traditional research efforts.
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DOI：
10.1084/jem.20001021
发表时间：
2002-03-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blattman JN;Antia R;Sourdive DJ;Wang X;Kaech SM;Murali-Krishna K;Altman JD;Ahmed R
通讯作者：
Ahmed R
DOI：
10.1084/jem.186.8.1223
发表时间：
1997-10-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brocker T
通讯作者：
Brocker T
影响因子：
4.4
作者：
Chen, Yingying;Perussia, Bice;Campbell, Kerry S.
通讯作者：
Campbell, Kerry S.
影响因子：
5.5
作者：
Dubois, B;Bridon, JM;Brière, F
通讯作者：
Brière, F
影响因子：
56.9
作者：
Chen, M;Wang, YH;Wang, J
通讯作者：
Wang, J