Selective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging.
Selective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging.
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脑老化期间N-甲基-D-天冬氨酸（NMDA）受体的选择性脆弱性。
DOI：
10.3389/fnagi.2010.00011
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发表时间：
2010
影响因子：
4.8
通讯作者：
Das, Siba R.
中科院分区：
文献类型：
--
作者：
Magnusson, Kathy R.;Brim, Brenna L.;Das, Siba R.
N-甲基-D-天冬氨酸（NMDA）受体以高密度存在于大脑皮层和海马中，并在学习和记忆中起重要作用。NMDA受体受到衰老的负面影响，但这些影响在许多不同的方面并不一致。这篇综述讨论了选择性年龄相关的脆弱性的不同结合位点的NMDA受体复合物，不同的亚基，包括复杂的，和不同的大脑区域内的受体的表达和功能。空间参照、被动回避、工作记忆以及位置场的稳定性和扩展都涉及NMDA受体。与年轻动物相比，老年动物在这些功能方面表现出缺陷，一些研究已经确定了NMDA受体表达的年龄相关变化与记忆力低下之间的关联。一些饮食和药物干预措施已显示出逆转或减缓衰老对NMDA受体影响的潜力。另一方面，越来越多的证据表明，老年人体内的NMDA受体并不总是与良好的认知功能相关。这可能是由于神经元对NMDA受体表达下降或其余受体亚基组成变化的代偿反应。这些研究表明，开发旨在预防或逆转衰老对NMDA受体影响的治疗方法可能有助于改善与衰老相关的记忆力下降。然而，我们需要注意的是，老年人也可能有负面影响。
N-methyl-D-aspartate (NMDA) receptors are present in high density within the cerebral cortex and hippocampus and play an important role in learning and memory. NMDA receptors are negatively affected by aging, but these effects are not uniform in many different ways. This review discusses the selective age-related vulnerabilities of different binding sites of the NMDA receptor complex, different subunits that comprise the complex, and the expression and functions of the receptor within different brain regions. Spatial reference, passive avoidance, and working memory, as well as place field stability and expansion all involve NMDA receptors. Aged animals show deficiencies in these functions, as compared to young, and some studies have identified an association between age-associated changes in the expression of NMDA receptors and poor memory performance. A number of diet and drug interventions have shown potential for reversing or slowing the effects of aging on the NMDA receptor. On the other hand, there is mounting evidence that the NMDA receptors that remain within aged individuals are not always associated with good cognitive functioning. This may be due to a compensatory response of neurons to the decline in NMDA receptor expression or a change in the subunit composition of the remaining receptors. These studies suggest that developing treatments that are aimed at preventing or reversing the effects of aging on the NMDA receptor may aid in ameliorating the memory declines that are associated with aging. However, we need to be mindful of the possibility that there may also be negative consequences in aged individuals.
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影响因子：
16.2
作者：
Barria, A;Malinow, R
通讯作者：
Malinow, R
影响因子：
5.3
作者：
Adams, MM;Oung, T;Gore, AC
通讯作者：
Gore, AC
影响因子：
3.3
作者：
Andrés, N;Rodríguez, MJ;Mahy, N
通讯作者：
Mahy, N
DOI：
10.1037/h0081022
发表时间：
1980-01-01
期刊：
CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE
影响因子：
--
作者：
BARNES, CA;NADEL, L;HONIG, WK
通讯作者：
HONIG, WK
DOI：
10.1037/h0077579
发表时间：
1979-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BARNES, CA
通讯作者：
BARNES, CA