Arrowsmith two-node search interface: a tutorial on finding meaningful links between two disparate sets of articles in MEDLINE.
Arrowsmith two-node search interface: a tutorial on finding meaningful links between two disparate sets of articles in MEDLINE.
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DOI：
10.1016/j.cmpb.2008.12.006
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发表时间：
2009-05
影响因子：
6.1
通讯作者：
Zhou W
中科院分区：
文献类型：
--
作者：
Smalheiser NR;Torvik VI;Zhou W
阿罗史密斯双节点搜索是一种策略，旨在帮助生物医学研究人员制定和评估科学假设。更一般地说，它允许用户识别PubMed中任何两组文章A和C之间的生物学意义的链接，即使这些文章或作者没有共同之处，并且代表不同的主题或学科。其关键思想是通过它们共享的标题词和短语（B术语）将两组文章联系起来。我们已经创建了一个免费的，公共的基于Web的版本的两个节点的搜索工具（http：arrowsmith.psych.uic.edu），描述了它的开发和实现，并提出了个人的两个节点的搜索分析。在本文中，我们为最终用户提供了一个更新的教程，涵盖了该工具在各种潜在科学用例场景中的使用。例如，人们可以评估最近的实验，临床或流行病学发现，连接两个不同的调查领域-确定可能的机制来解释发现，并选择有希望的后续调查路线。或者，可以评估现有的科学文献是否间接支持用户提出的尚未调查的假设。也可以采用双节点搜索来搜索新的假设。Arrowsmith提供的服务无法通过标准的PubMed搜索或其他可用的文本挖掘工具进行。
The Arrowsmith two-node search is a strategy that is designed to assist biomedical investigators in formulating and assessing scientific hypotheses. More generally, it allows users to identify biologically meaningful links between any two sets of articles A and C in PubMed, even when these share no articles or authors in common and represent disparate topics or disciplines. The key idea is to relate the two sets of articles via title words and phrases (B-terms) that they share. We have created a free, public web-based version of the two-node search tool (http://arrowsmith.psych.uic.edu), have described its development and implementation, and have presented analyses of individual two-node searches. In this paper, we provide an updated tutorial intended for end-users, that covers the use of the tool for a variety of potential scientific use case scenarios. For example, one can assess a recent experimental, clinical or epidemiologic finding that connects two disparate fields of inquiry -- identifying likely mechanisms to explain the finding, and choosing promising follow-up lines of investigation. Alternatively, one can assess whether the existing scientific literature lends indirect support to a hypothesis posed by the user that has not yet been investigated. One can also employ two-node searches to search for novel hypotheses. Arrowsmith provides a service that cannot be carried out feasibly via standard PubMed searches or by other available text mining tools.
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影响因子：
3
作者：
Wren JD
通讯作者：
Wren JD
影响因子：
5.3
作者：
Noctor, SC;Flint, AC;Kriegstein, AR
通讯作者：
Kriegstein, AR
DOI：
10.1002/asi.20105
发表时间：
2005-01-15
影响因子：
--
作者：
Torvik, VI;Weeber, M;Smalheiser, NR
通讯作者：
Smalheiser, NR
影响因子：
9.9
作者：
Smalheiser, NR;Swanson, DR
通讯作者：
Swanson, DR
DOI：
10.1016/j.ijmedinf.2004.04.024
发表时间：
2005-03-01
影响因子：
4.9
作者：
Hristovski, D;Peterlin, B;Humphrey, SM
通讯作者：
Humphrey, SM