Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration.
Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration.
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DOI：
10.1016/j.ophtha.2014.01.034
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发表时间：
2014-07
期刊：
影响因子：
13.7
通讯作者：
Huang D
中科院分区：
文献类型：
--
作者：
Jia Y;Bailey ST;Wilson DJ;Tan O;Klein ML;Flaxel CJ;Potsaid B;Liu JJ;Lu CD;Kraus MF;Fujimoto JG;Huang D
采用光学相干断层扫描（OCT）血管造影术检测和量化年龄相关性黄斑变性（AMD）患者的脉络膜新生血管（CNV）。观察性横断面研究。包括5名正常受试者和5名新生血管性AMD患者。5例新生血管性AMD患者和5例年龄匹配的正常对照者接受1050 nm波长扫描OCT扫描。黄斑血管造影扫描覆盖3×3 mm区域，包括3.5秒内采集的200×200×8次A扫描。使用分裂频谱振幅去相关血管造影（SSADA）算法检测血流。通过三维（3D）正交配准和合并4个扫描消除运动伪影。3D血管造影分为3层：内层视网膜（显示视网膜血管）、外层视网膜（识别CNV）和脉络膜。使用正面最大投影从3个层获得2D血管造影片。CNV面积和血流指数由视网膜外层的正面OCT血管造影计算。血流（去相关）和结构数据结合在复合彩色血管造影片中，用于正面和横截面视图。CNV血管造影、CNV面积和CNV血流指数。CNVs的正面OCT血管造影显示了荧光素血管造影证实的大小和位置。OCT血管造影提供了更清晰的血管网络模式，较少被视网膜下出血所掩盖。正面血管造影还显示所有病例中CNV附近脉络膜血流减少，1例病例中视网膜血流明显减少。使用横截面血管造影来可视化CNV相对于视网膜色素上皮和Bruch层的位置，并将I型和II型CNV分类。在1例病例中可识别出供血血管。较高的血流指数与较大的CNV和II型CNV相关。OCT血管造影提供了新生血管性AMD中CNV的深度分辨信息和详细图像。可以获得关于CNV流量和面积的定量信息。定量OCT血管造影在新生血管性AMD的评价和治疗中的作用还需要进一步研究。
To detect and quantify choroidal neovascularization (CNV) in age-related macular degeneration (AMD) patients using optical coherence tomography (OCT) angiography. Observational, cross-sectional study. Five normal subjects and five neovascular AMD patients were included. Five eyes with neovascular AMD and five normal age-matched controls were scanned by a high-speed (100,000 A-scans/sec) 1050 nm wavelength swept-source OCT. The macular angiography scan covered a 3×3 mm area and comprised 200×200×8 A-scans acquired in 3.5 sec. Flow was detected using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. Motion artifacts were removed by three dimensional (3D) orthogonal registration and merging of 4 scans. The 3D angiography was segmented into 3 layers: inner retina (to show retinal vasculature), outer retina (to identify CNV), and choroid. En face maximum projection was used to obtain 2D angiograms from the 3 layers. CNV area and flow index were computed from the en face OCT angiogram of the outer retinal layer. Flow (decorrelation) and structural data were combined in composite color angiograms for both en face and cross-sectional views. CNV angiogram, CNV area, and CNV flow index. En face OCT angiograms of CNVs showed sizes and locations that were confirmed by fluorescein angiography. OCT angiography provided more distinct vascular network patterns that were less obscured by subretinal hemorrhage. The en face angiograms also showed areas of reduced choroidal flow adjacent to the CNV in all cases and significantly reduced retinal flow in one case. Cross-sectional angiograms were used to visualize CNV location relative to the retinal pigment epithelium and Bruch’s layer and classify type I and type II CNV. A feeder vessel could be identified in one case. Higher flow indexes were associated with larger CNV and type II CNV. OCT angiography provides depth-resolved information and detailed images of CNV in neovascular AMD. Quantitative information regarding CNV flow and area can be obtained. Further studies are needed to assess the role of quantitative OCT angiography in the evaluation and treatment of neovascular AMD.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.4
作者：
Kraus MF;Potsaid B;Mayer MA;Bock R;Baumann B;Liu JJ;Hornegger J;Fujimoto JG
通讯作者：
Fujimoto JG
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
3.4
作者：
Baumann B;Potsaid B;Kraus MF;Liu JJ;Huang D;Hornegger J;Cable AE;Duker JS;Fujimoto JG
通讯作者：
Fujimoto JG
影响因子：
10.6
作者：
Chan, TF;Vese, LA
通讯作者：
Vese, LA